Showing entry for Serine/threonine-protein phosphatase 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010968
Protein NameSerine/threonine-protein phosphatase 5
Uniport IdP53041
GenePPP5C
Gene Id5536
DomainMetallophos; PPP5; TPR_1
Pfam PF00149   PF08321   PF00515  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071276 cellular response to cadmium ion
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0006281 DNA repair
Biological Process GO:0016576 histone dephosphorylation
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0070262 peptidyl-serine dephosphorylation
Biological Process GO:0035970 peptidyl-threonine dephosphorylation
Biological Process GO:2000324 positive regulation of glucocorticoid receptor signaling pathway
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:1904550 response to arachidonic acid
Biological Process GO:0010288 response to lead ion
Biological Process GO:0043278 response to morphine
Biological Process GO:0006351 transcription, DNA-templated
molecular function GO:0043531 ADP binding
molecular function GO:0005524 ATP binding
molecular function GO:0001965 G-protein alpha-subunit binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008289 lipid binding
molecular function GO:0046872 metal ion binding
molecular function GO:0008017 microtubule binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0004722 protein serine/threonine phosphatase activity
molecular function GO:0003723 RNA binding
molecular function GO:0048156 tau protein binding
cellular component GO:0101031 chaperone complex
cellular component GO:0005829 cytosol
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:1990635 proximal dendrite
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-73894 DNA Repair
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017638 BXGD001132 Glioma Neoplasms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0022602 BXGD001564 Actinic keratosis Neoplasms; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027877 BXGD002055 Neuronal Ceroid-Lipofuscinoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0268281 BXGD005882 Infantile neuronal ceroid lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0271815 BXGD006264 Postpartum Thyroiditis Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0553642 BXGD009403 Soft tissue rheumatism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1629609 BXGD013479 Age at menopause
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931673 BXGD018046 Ceroid lipofuscinosis, neuronal 1, infantile Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein