Showing entry for Diabetic peripheral neuropathy


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD009998
Disease NameDiabetic peripheral neuropathy
Disease CUI IdC0740447
MeSH Codes C10   C19  
Disease Class NameNervous System Diseases; Endocrine System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O75460 BXGT005127 Serine/threonine-protein kinase/endoribonuclease IRE1 2081 reviewed Kinase
O75636 BXGT005141 Ficolin-3 8547 reviewed Signaling
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
O95342 BXGT005373 Bile salt export pump 8647 reviewed Transporter
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04278 BXGT006182 Sex hormone-binding globulin 6462 reviewed
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P07093 BXGT006544 Glia-derived nexin 5270 reviewed Enzyme modulator
P07203 BXGT006566 Glutathione peroxidase 1 2876 reviewed Enzyme
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 231 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16050 BXGT008184 Arachidonate 15-lipoxygenase 246 reviewed Enzyme
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 6198 reviewed Kinase
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 2324 reviewed Kinase
P36956 BXGT009947 Sterol regulatory element-binding protein 1 6720 reviewed
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41252 BXGT010245 Isoleucine--tRNA ligase, cytoplasmic 3376 reviewed Enzyme
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43220 BXGT010367 Glucagon-like peptide 1 receptor 2740 reviewed G-protein coupled receptor
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P55789 BXGT011126 FAD-linked sulfhydryl oxidase ALR 2671 reviewed Enzyme
P78536 BXGT011847 Disintegrin and metalloproteinase domain-containing protein 17 6868 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q00059 BXGT012512 Transcription factor A, mitochondrial 7019 reviewed
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q14416 BXGT013468 Metabotropic glutamate receptor 2 2912 reviewed G-protein coupled receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q15858 BXGT013610 Sodium channel protein type 9 subunit alpha 6335 reviewed Ion channel
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q9H244 BXGT020448 P2Y purinoceptor 12 64805 reviewed G-protein coupled receptor
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease