Showing entry for Serine/threonine-protein kinase/endoribonuclease IRE1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005127
Protein NameSerine/threonine-protein kinase/endoribonuclease IRE1
Uniport IdO75460
GeneERN1
Gene Id2081
DomainPkinase; Ribonuc_2-5A
Pfam PF00069   PF06479  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0034620 cellular response to unfolded protein
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0001935 endothelial cell proliferation
Biological Process GO:1901142 insulin metabolic process
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0006379 mRNA cleavage
Biological Process GO:0098787 mRNA cleavage involved in mRNA processing
Biological Process GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation
Biological Process GO:0036289 peptidyl-serine autophosphorylation
Biological Process GO:1990579 peptidyl-serine trans-autophosphorylation
Biological Process GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
Biological Process GO:0033120 positive regulation of RNA splicing
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0034976 response to endoplasmic reticulum stress
molecular function GO:0043531 ADP binding
molecular function GO:0005524 ATP binding
molecular function GO:0004521 endoribonuclease activity
molecular function GO:0019899 enzyme binding
molecular function GO:0030544 Hsp70 protein binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0005161 platelet-derived growth factor receptor binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0051082 unfolded protein binding
cellular component GO:1990597 AIP1-IRE1 complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0030176 integral component of endoplasmic reticulum membrane
cellular component GO:1990332 Ire1 complex
cellular component GO:1990630 IRE1-RACK1-PP2A complex
cellular component GO:1990604 IRE1-TRAF2-ASK1 complex
cellular component GO:0005739 mitochondrion
cellular component GO:0005637 nuclear inner membrane
Reactome
Pathway Id Pathway Name
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006277 BXGD000387 Bronchitis Infections; Respiratory Tract Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016514 BXGD001066 Foot-and-Mouth Disease Infections; Animal Diseases
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020877 BXGD001471 Ileitis Digestive System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035869 BXGD002569 Rotavirus Infections Infections
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043207 BXGD003038 Wolfram Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153252 BXGD003616 Systemic candidiasis Infections
C0175697 BXGD004004 Van der Woude syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206750 BXGD004287 Coronavirus Infections Infections
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0236018 BXGD004804 Aura Nervous System Diseases
C0239849 BXGD005003 Harlequin Fetus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280313 BXGD006737 Squamous cell carcinoma of oropharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0343890 BXGD007653 Systemic cryptococcosis Pathological Conditions, Signs and Symptoms; Infections
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740447 BXGD009998 Diabetic peripheral neuropathy Nervous System Diseases; Endocrine System Diseases
C0747845 BXGD010184 early pregnancy
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0752304 BXGD010711 Hypoxic-Ischemic Encephalopathy Nervous System Diseases; Cardiovascular Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1135191 BXGD011692 Heart Failure, Systolic Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1868720 BXGD016531 Periventricular Nodular Heterotopia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2349952 BXGD017065 Oropharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4509226 BXGD022972 Heart failure with preserved ejection fraction [HFpEF]
C4529962 BXGD023178 Fatty Liver Disease
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0002748 Salicaldehyde 122.12
BXGC0003705 Chloride 35.45
BXGC0034886 2-Hydroxy-3-Methoxybenzaldehyde 152.05
BXGC0037639 2,3-Dihydroxybenzaldehyde 138.03
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein