Showing entry for Bile salt export pump


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005373
Protein NameBile salt export pump
Uniport IdO95342
GeneABCB11
Gene Id8647
DomainABC_membrane; ABC_tran
Pfam PF00664   PF00005  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
3. Environmental Information Processing 3.1 Membrane transport hsa02010 ABC transporters
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015721 bile acid and bile salt transport
Biological Process GO:0006699 bile acid biosynthetic process
Biological Process GO:0008206 bile acid metabolic process
Biological Process GO:0015722 canalicular bile acid transport
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0046618 drug export
Biological Process GO:0017144 drug metabolic process
Biological Process GO:0006855 drug transmembrane transport
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0055091 phospholipid homeostasis
Biological Process GO:0120189 positive regulation of bile acid secretion
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:1904251 regulation of bile acid metabolic process
Biological Process GO:0031998 regulation of fatty acid beta-oxidation
Biological Process GO:0055085 transmembrane transport
molecular function GO:0016887 ATPase activity
molecular function GO:0015432 ATPase-coupled bile acid transmembrane transporter activity
molecular function GO:0042626 ATPase-coupled transmembrane transporter activity
molecular function GO:0008559 ATPase-coupled xenobiotic transmembrane transporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0015125 bile acid transmembrane transporter activity
molecular function GO:0015126 canalicular bile acid transmembrane transporter activity
molecular function GO:0008554 sodium transmembrane transporter activity, phosphorylative mechanism
molecular function GO:0005215 transporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0046581 intercellular canaliculus
cellular component GO:0046691 intracellular canaliculus
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0055038 recycling endosome membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-159418 Recycling of bile acids and salts
R-HSA-1643685 Disease
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-5619084 ABC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5678520 Defective ABCB11 causes PFIC2 and BRIC2
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001306 BXGD000037 Acute alcoholic liver disease Digestive System Diseases; Chemically-Induced Disorders; Mental Disorders
C0001733 BXGD000073 Afibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004623 BXGD000282 Bacterial Infections Infections
C0005411 BXGD000313 Biliary Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008352 BXGD000532 Cholemia
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017741 BXGD001149 Glucose tolerance test
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0027613 BXGD002004 Neonatal hepatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0037889 BXGD002709 Hereditary spherocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0042842 BXGD003005 Vitamin A Deficiency Nutritional and Metabolic Diseases
C0085280 BXGD003151 Alagille Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Cardiovascular Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0149841 BXGD003372 Benign recurrent intrahepatic cholestasis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0201836 BXGD004052 Alanine aminotransferase measurement
C0201850 BXGD004053 Alkaline phosphatase measurement
C0201899 BXGD004056 Aspartate aminotransferase measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0221152 BXGD004392 Obstipation Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0268307 BXGD005892 Conjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0268312 BXGD005894 Progressive intrahepatic cholestasis (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0271790 BXGD006259 Subclinical hypothyroidism Endocrine System Diseases
C0332853 BXGD006901 Anastomosis
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0341306 BXGD007401 Microvillus inclusion disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0349588 BXGD007933 Short stature
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426576 BXGD008571 Gastrointestinal symptom Pathological Conditions, Signs and Symptoms
C0427460 BXGD008616 Red cell distribution width determination
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428568 BXGD008633 Fasting blood glucose measurement
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0554103 BXGD009423 Intestinal malabsorption of fat Digestive System Diseases; Nutritional and Metabolic Diseases
C0557874 BXGD009444 Global developmental delay
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740447 BXGD009998 Diabetic peripheral neuropathy Nervous System Diseases; Endocrine System Diseases
C0742395 BXGD010062 Cholestasis, chronic
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0751753 BXGD010576 Carbamoyl-Phosphate Synthase I Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0856727 BXGD011108 Cholesterol gallstones Digestive System Diseases
C0860204 BXGD011219 Cholestatic liver disease Digestive System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C1261430 BXGD011853 Fasting blood sugar result
C1278049 BXGD012114 Serum gamma-glutamyl transferase measurement
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1443924 BXGD013074 Severe diarrhea Pathological Conditions, Signs and Symptoms
C1445957 BXGD013081 Serum total cholesterol measurement
C1611743 BXGD013456 Familial (FPAH)
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1843392 BXGD014582 Death in childhood
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C1865349 BXGD016317 Ethylmalonic encephalopathy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C1865643 BXGD016337 Cholestasis, progressive familial intrahepatic 3 Digestive System Diseases
C1883008 BXGD016593 Serum Alanine Aminotransferase Measurement
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2584774 BXGD017130 Congenital hypofibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2608083 BXGD017155 Cholestasis, benign recurrent intrahepatic 2 Digestive System Diseases
C2609268 BXGD017175 Low phospholipid-associated cholelithiasis Digestive System Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3489789 BXGD018948 Cholestasis, Progressive Familial Intrahepatic, 2 Digestive System Diseases
C3554241 BXGD019206 CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY 3
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4021883 BXGD020828 Abnormal liver function tests during pregnancy
C4025805 BXGD021798 Intermittent jaundice Pathological Conditions, Signs and Symptoms
C4048329 BXGD021904 Immunosuppression
C4049431 BXGD021931 Chronic hepatitis C genotype 4
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4551898 BXGD023434 Cholestasis, progressive familial intrahepatic 1 Digestive System Diseases
C4551899 BXGD023435 Cholestasis, benign recurrent intrahepatic 1 Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000286 L-DOPA 197.19
BXGC0000290 Pyridoxine 169.18
BXGC0000528 Salicylic acid 138.12
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000663 Papain 206.28
BXGC0000759 Arabinan 243.22
BXGC0000894 2-Methylthioribosyl-trans-zeatin 323.8
BXGC0001000 4,8,5'-Trimethylpsoralen 228.24
BXGC0001325 Progesterone 314.46
BXGC0001502 Caffeine 194.19
BXGC0001515 Cinchonidine 294.39
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001589 Arecoline 155.19
BXGC0002402 Ethyl carbamate 89.09
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002735 Carotene 536.89
BXGC0002796 Nicotine 162.23
BXGC0002867 Lappaurin 284.74
BXGC0002916 Melatonin 232.28
BXGC0003102 Acetylcholine 146.21
BXGC0003196 Aripiprazole 448.39
BXGC0003464 Satiomem 290.79
BXGC0003690 Glucokinin 764.94
BXGC0003773 Estriol 288.38
BXGC0003879 Docosan-1-ol 326.6
BXGC0003956 Fenugrin E 178.19
BXGC0004119 Synepherine 167.21
BXGC0004667 Betaine 117.15
BXGC0005638 Undecylenic acid 184.28
BXGC0005668 2-Methoxyphenol 124.14
BXGC0005683 Quercetin 302.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005871 Dopamine 153.18
BXGC0006034 Phytomenadione 450.7
BXGC0006156 Dicoumarol 336.3
BXGC0006362 Estrone 270.37
BXGC0006372 Ergocalciferol 396.65
BXGC0006389 Rotenone 394.42
BXGC0006422 Mercenene 214.05
BXGC0007530 Folic acid 441.4
BXGC0008140 Tetramethylpyrazine 136.19
BXGC0012243 Ukonan D 151.16
BXGC0013854 Histamine 111.08
BXGC0014695 Loratadine 382.14
BXGC0015733 6,7-Dimethoxy-3-(6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)-3H-2-Benzofuran-1-One 383.14
BXGC0016470 Camptothecin 348.11
BXGC0016671 Leucovorin 473.17
BXGC0016891 Nortriptyline 263.17
BXGC0018063 Alprenolol 249.17
BXGC0018491 Methylprednisolone 374.21
BXGC0018962 dibenzothiophene 184.03
BXGC0020800 Testosterone 288.21
BXGC0021478 Lipoic Acid 206.04
BXGC0021716 (R)-Verapamil 454.28
BXGC0021893 Norepinephrine 169.07
BXGC0022231 Ursodiol 392.29
BXGC0022544 Digoxin 780.43
BXGC0023872 Adenine 135.05
BXGC0024141 Hydrocortisone 362.21
BXGC0024413 Emetine 480.3
BXGC0024729 Mercaptopurine 152.02
BXGC0024988 Nifedipine 346.12
BXGC0025404 Mephenesin 182.09
BXGC0025658 Vinblastine 810.42
BXGC0026391 Naloxone 327.15
BXGC0026825 pantolactone 130.06
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0027854 Ethosuximide 141.08
BXGC0028104 Hyoscyamine 289.17
BXGC0028727 noscapine 413.15
BXGC0030099 Salicin 286.11
BXGC0030138 Colchicine 399.17
BXGC0030663 Metformin 129.1
BXGC0030685 Physostigmine 275.16
BXGC0030901 Morphine 285.14
BXGC0031618 Vinblastine 810.42
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0034035 Capsaicin 305.2
BXGC0034783 Doxorubicin 543.17
BXGC0035201 Quinidine 324.18
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038233 Nalidixic Acid 232.08
BXGC0040042 Warfarin 308.1
BXGC0040364 Artesunate 384.18
BXGC0040850 artemisinine 282.15
BXGC0040949 Hydroxyprogesterone Caproate 428.29
BXGC0041240 Atenolol 266.16
BXGC0042127 Oxyquinoline 145.05
BXGC0042139 (3,4,8B-Trimethyl-2,3A-Dihydro-1H-Pyrrolo[2,3-B]Indol-7-Yl) N-Methylcarbamate 275.16
BXGC0042179 Atropine 289.17
BXGC0042222 Propranolol 259.16
BXGC0042339 Terbutaline 225.14
BXGC0042413 Calcitriol 416.33
BXGC0042510 Fluoxetine 309.13
BXGC0042519 Glimepiride 490.22
BXGC0042596 Isoniazid 137.06
BXGC0043126 Nicardipine 479.21
BXGC0043587 Scopolamine 303.15
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
BXGC0045812 Trifluoperazine 407.16
BXGC0046139 Aminoglutethimide 232.12
BXGC0046518 Chloroquine 319.18
BXGC0046755 Yohimbine 354.19
BXGC0047126 Artemether 298.18
BXGC0047692 Gefitinib 446.15
BXGC0048190 Pantothenic Acid 219.11
BXGC0050245 Pentostatin 268.12
BXGC0050471 Fluorouracil 130.02
BXGC0050816 Galantamine 287.15
BXGC0051524 Ouabain 584.28
BXGC0052374 Reserpine 608.27
BXGC0052646 Tubocurarine 609.3
BXGC0053118 Streptomycin 581.27
BXGC0053261 Antimycin A 548.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein