Showing entry for Aldo-keto reductase family 1 member A1



                       
General Target Information
BXGT IdBXGT008019
Protein NameAldo-keto reductase family 1 member A1
Uniport IdP14550
GeneAKR1A1
Gene Id10327
DomainAldo_ket_red
Pfam PF00248  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis
1. Metabolism 1.1 Carbohydrate metabolism hsa00040 Pentose and glucuronate interconversions
1. Metabolism 1.3 Lipid metabolism hsa00561 Glycerolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046185 aldehyde catabolic process
Biological Process GO:0006081 cellular aldehyde metabolic process
Biological Process GO:0110095 cellular detoxification of aldehyde
Biological Process GO:0044597 daunorubicin metabolic process
Biological Process GO:0042840 D-glucuronate catabolic process
Biological Process GO:0044598 doxorubicin metabolic process
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0019640 glucuronate catabolic process to xylulose 5-phosphate
Biological Process GO:1901687 glutathione derivative biosynthetic process
Biological Process GO:0019853 L-ascorbic acid biosynthetic process
molecular function GO:0008106 alcohol dehydrogenase (NADP+) activity
molecular function GO:0004032 alditol:NADP+ 1-oxidoreductase activity
molecular function GO:0004033 aldo-keto reductase (NADP) activity
molecular function GO:0047655 allyl-alcohol dehydrogenase activity
molecular function GO:0009055 electron transfer activity
molecular function GO:0047941 glucuronolactone reductase activity
molecular function GO:0047939 L-glucuronate reductase activity
molecular function GO:0016491 oxidoreductase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156590 Glutathione conjugation
R-HSA-211859 Biological oxidations
R-HSA-5661270 Formation of xylulose-5-phosphate
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001969 BXGD000094 Alcoholic Intoxication Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002963 BXGD000161 Angina Pectoris, Variant Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003969 BXGD000245 Ascorbic Acid Deficiency Nutritional and Metabolic Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004606 BXGD000279 Nonproliferative diabetic retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006849 BXGD000413 Oral candidiasis Infections; Stomatognathic Diseases
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0014474 BXGD000917 Ependymoma Neoplasms
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015732 BXGD001018 Fecal Incontinence Digestive System Diseases
C0015923 BXGD001023 Fetal Alcohol Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Chemically-Induced Disorders
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023051 BXGD001602 Laryngeal Diseases Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023891 BXGD001714 Liver Cirrhosis, Alcoholic Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Chemically-Induced Disorders
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085409 BXGD003168 Polyendocrinopathies, Autoimmune Immune System Diseases; Endocrine System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0153398 BXGD003631 Hypopharyngeal Cancer Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0153405 BXGD003632 Malignant neoplasm of pharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0154830 BXGD003746 Proliferative diabetic retinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0156312 BXGD003849 Atrophy of testis Male Urogenital Diseases; Endocrine System Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0221100 BXGD004389 Hangover from any Alcohol or Other Drugs substance
C0231557 BXGD004500 Abnormal bone formation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0240765 BXGD005053 Acquired pectus carinatum Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0271093 BXGD006162 Stargardt's disease
C0276653 BXGD006438 Invasive Pulmonary Aspergillosis Infections; Respiratory Tract Diseases
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278874 BXGD006605 Adult Ependymoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280280 BXGD006731 stage, prostate cancer Neoplasms; Male Urogenital Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0342257 BXGD007447 Complications of Diabetes Mellitus Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349464 BXGD007908 Wernicke-Korsakoff Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0375021 BXGD007969 Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376670 BXGD008007 Pancreatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0393756 BXGD008138 Hangover from alcohol Chemically-Induced Disorders; Mental Disorders
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0426576 BXGD008571 Gastrointestinal symptom Pathological Conditions, Signs and Symptoms
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0549393 BXGD009374 Alcohol problem
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679414 BXGD009775 alcohol flush reaction Pathological Conditions, Signs and Symptoms; Chemically-Induced Disorders; Mental Disorders
C0683342 BXGD009784 hazardous drinking
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0687132 BXGD009839 heavy drinking
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700345 BXGD009886 Candidiasis, Vulvovaginal Female Urogenital Diseases and Pregnancy Complications; Infections
C0740447 BXGD009998 Diabetic peripheral neuropathy Nervous System Diseases; Endocrine System Diseases
C0747198 BXGD010164 pancreatitis idiopathic
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0796611 BXGD010835 Newly Diagnosed Childhood Ependymoma Neoplasms
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0949059 BXGD011568 Polyp of large intestine Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1260386 BXGD011828 Glucocorticoid-remediable aldosteronism Endocrine System Diseases
C1262313 BXGD011881 Invasive Fungal Infections Infections
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333762 BXGD012639 Gastric Cardia Adenocarcinoma
C1368404 BXGD012899 Hypopharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C1531773 BXGD013302 Currarino triad Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nervous System Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1707444 BXGD013586 Columnar Cell Change of the Breast
C1848641 BXGD014955 Profound sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1851584 BXGD015221 Childhood Ependymoma Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2985290 BXGD018224 Fetal Alcohol Spectrum Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Chemically-Induced Disorders
C3146244 BXGD018257 Alcohol Related Birth Defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Chemically-Induced Disorders
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3495676 BXGD019000 Anorectal Malformations Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000063 Galloyl glucose 332.26
BXGC0001881 Chrysophanol 254.24
BXGC0002616 Copper 63.55
BXGC0007029 Emodin 270.24
BXGC0034783 Doxorubicin 543.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein