Showing entry for Duvoglustat


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0041132
Compound NameDuvoglustat
Structure
FormulaC6H13NO4
InchiKeyLXBIFEVIBLOUGU-JGWLITMVSA-N
SMILESOC[C@H]1NC[C@@H]([C@H]([C@@H]1O)O)O
InchiInChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
IUPAC(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
Molecular Weight163.08
Pubchem Id29435
Chembl IdCHEMBL307429
Targets of Information Source
DrugBank DB03206
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q9UKM7 BXGT021747 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase reviewed Chaperone MAN1B1 investigational -
P31723 BXGT009573 Mannosyl-oligosaccharide alpha-1,2-mannosidase reviewed - MSDC investigational -
P12070 BXGT007770 Xylose isomerase reviewed - xylA investigational -
Q08638 BXGT012997 Beta-glucosidase A reviewed - bglA investigational -
P05618 BXGT006369 Cyclomaltodextrin glucanotransferase reviewed - cgt investigational -
PDB NOJ
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P12070 BXGT007770 Xylose isomerase reviewed xylA - - - - -
P69327 BXGT011625 Glucoamylase reviewed GLAA - 96000 - - -
P05618 BXGT006369 Cyclomaltodextrin glucanotransferase reviewed cgt - - - - -
Q08638 BXGT012997 Beta-glucosidase A reviewed bglA - - - 4762 -
Q08638 BXGT012997 Beta-glucosidase A reviewed bglA - 4000 - - -
G8JZS4 BXGT003556 Glucan 1,4-alpha-glucosidase SusB reviewed susB - 59000 - - -
Q2PS28 BXGT014157 Sucrose isomerase unreviewed mutB - 40000 - - -
Q9STC1 BXGT021609 Alpha-1,4-glucan lyase isozyme 1 unreviewed Ag111 - - - - -
P16098 BXGT008191 Beta-amylase reviewed BMY1 - - - - -
A0A0H2UNG0 BXGT000233 Putative alkaline amylopullulanase unreviewed SP_0268 - - - - -
D0VX20 BXGT002768 Sucrose isomerase SmuA from Protaminobacter rubrum unreviewed smuA - 10000 - - -
P06280 BXGT006433 Alpha-galactosidase A reviewed GLA - - - - -
O66264 BXGT004938 Cellobiose Phosphorylase unreviewed - - - - -
Q8T0W7 BXGT018771 Beta-glucosidase unreviewed NkBG - - - - -
P00698 BXGT005617 Lysozyme C reviewed LYZ - - - - -
P48825 BXGT010665 Beta-glucosidase 1 reviewed - 2400 - - -
F6BL85 BXGT003291 Glucosylceramidase unreviewed Thexy_2211 - 130 - - -
G0SG42 BXGT003413 Alpha glucosidase-like protein unreviewed CTHT_0064960 - - - - -
Q8BHN3 BXGT017912 Neutral alpha-glucosidase AB reviewed Ganab - - - - -
Q8A2J3 BXGT017799 Glucosylceramidase unreviewed BT_3312 - - - - -
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed GAA Enzyme 3400 - - -
O06994 BXGT003997 Oligo-1,6-glucosidase 1 reviewed malL - - - - -
A8CFR3 BXGT023995 Beta-amylase unreviewed Bmy1 - - - - -
H9J974 BXGT024767 Aamy domain-containing protein unreviewed - - - - -
Q9I311 BXGT025408 Periplasmic beta-glucosidase unreviewed bglX - - - - -
Binding DB 18351
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA 79000 240000 - -
reviewed BXGT009243 Protein-lysine 6-oxidase reviewed LOX - 1000 - -
reviewed BXGT010030 Alpha-glucosidase MAL32 reviewed MAL32 - 250000 - -
reviewed BXGT013315 Oxysterols receptor LXR-alpha reviewed Nuclear receptor NR1H3 - >100000 - -
reviewed BXGT011101 Oxysterols receptor LXR-beta reviewed Nuclear receptor NR1H2 - >100000 - -
reviewed BXGT010983 Alpha-glucosidase MAL12 reviewed MAL12 18000 39500 - -
reviewed BXGT012486 Trehalose synthase/amylase TreS reviewed treS 250 - - -
reviewed BXGT011681 Lysosomal alpha-glucosidase reviewed Gaa - - - 98800
reviewed BXGT010983 Alpha-glucosidase MAL12 reviewed MAL12 - 278000 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB 460000 - - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB 21000 - - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA 300000 - - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB 14 - - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB 160 - - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB 23000 - - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA - 118000 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA 150 - - -
reviewed BXGT015223 Beta-galactosidase reviewed GLB1 - 300000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 400 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB - 25000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 150000 - -
reviewed BXGT007574 Beta-glucosidase A reviewed bglA - 460000 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB - 570000 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB 410000 - - -
reviewed BXGT021111 Lysosomal alpha-glucosidase reviewed GAA - 21000 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB - 320000 - -
reviewed BXGT017923 Neutral alpha-glucosidase C reviewed Ganc - 940000 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB - 500000 - -
reviewed BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB - 1300 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 300 - -
reviewed BXGT009264 Alpha-mannosidase 2 reviewed Man2a1 - <50000 - -
reviewed BXGT012651 Lactase-phlorizin hydrolase reviewed Lct - 34000 - -
reviewed BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM - 360 - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA 79000 - - -
reviewed BXGT009152 Beta-glucosidase reviewed cbg-1 12000 - - -
reviewed BXGT009264 Alpha-mannosidase 2 reviewed Man2a1 <50000 - - -
reviewed BXGT008624 Alpha-mannosidase 2C1 reviewed Man2c1 - <50000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 210 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA - 1.5 - -
reviewed BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI - 2000 - -
reviewed BXGT006583 Alpha-glucosidase MAL62 reviewed MAL62 - 110000 - -
reviewed BXGT010971 Oligo-1,6-glucosidase IMA1 reviewed IMA1 - 330000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 360 - -
reviewed BXGT007574 Beta-glucosidase A reviewed bglA - 100000 - -
reviewed BXGT006433 Alpha-galactosidase A reviewed GLA 18000 - - -
reviewed BXGT020447 Cytosolic beta-glucosidase reviewed Enzyme GBA3 - 80000 - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA 2000 - - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si 24 - - -
reviewed BXGT020533 Non-lysosomal glucosylceramidase reviewed GBA2 - 20 - -
reviewed BXGT002376 Alpha-mannosidase reviewed - 270000 - - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA - 506000 - -
reviewed BXGT020533 Non-lysosomal glucosylceramidase reviewed GBA2 - 28800 - -
reviewed BXGT013663 Ceramide glucosyltransferase reviewed Enzyme UGCG - >100000 - -
reviewed BXGT020533 Non-lysosomal glucosylceramidase reviewed GBA2 - 21000 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA - 1500 - -
reviewed BXGT009850 Glycogen debranching enzyme reviewed Enzyme AGL - 10000 - -
reviewed BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM - 2000 - -
reviewed BXGT006929 Lactase-phlorizin hydrolase reviewed Enzyme LCT - 62000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 650 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 510 - -
reviewed BXGT012651 Lactase-phlorizin hydrolase reviewed Lct - 49000 - -
reviewed BXGT006142 Tissue alpha-L-fucosidase reviewed FUCA1 >100000000 - - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA - >300000 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA - 91900 - -
reviewed BXGT021111 Lysosomal alpha-glucosidase reviewed GAA - >300000 - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA 47000 - - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA 25000 - - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA - >500000 - -
reviewed BXGT021111 Lysosomal alpha-glucosidase reviewed GAA - 400 - -
reviewed BXGT017923 Neutral alpha-glucosidase C reviewed Ganc - 34000 - -
reviewed BXGT006142 Tissue alpha-L-fucosidase reviewed FUCA1 - 26000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 1000000 - -
reviewed BXGT012651 Lactase-phlorizin hydrolase reviewed Lct - 26000 - -
reviewed BXGT004582 Trehalase reviewed TREH - 40000 - -
reviewed BXGT007574 Beta-glucosidase A reviewed bglA - 55000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 360 - -
reviewed BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM - 40 - -
reviewed BXGT020447 Cytosolic beta-glucosidase reviewed Enzyme GBA3 - 240000 - -
reviewed BXGT016460 Lysosomal alpha-glucosidase reviewed Gaa - 130 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 160 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA - 1000 - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA - 240000 - -
reviewed BXGT009851 Glycogen debranching enzyme reviewed AGL - 190 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA - 60 - -
reviewed BXGT020533 Non-lysosomal glucosylceramidase reviewed GBA2 - 30000 - -
reviewed BXGT006140 Lysosomal acid glucosylceramidase reviewed GBA - 195000 - -
reviewed BXGT014115 Lysosomal acid glucosylceramidase reviewed GBA - 210000 - -
reviewed BXGT006583 Alpha-glucosidase MAL62 reviewed MAL62 - 425600000 - -
CHEMBL CHEMBL307429
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 - - -
Q8BVW0 BXGT017923 Neutral alpha-glucosidase C reviewed - Ganc IC50 '=' 940000 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 - - -
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 IC50 - - -
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 '=' 500000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 - - -
Q9MYM4 BXGT021111 Lysosomal alpha-glucosidase reviewed - GAA IC50 '>' 300000 nM
Q58DH9 BXGT015224 Alpha-N-acetylgalactosaminidase reviewed - NAGA Inhibition '<' 20 %
C0HJB3 BXGT002376 Alpha-mannosidase reviewed - Ki '=' 270000 nM
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 IC50 - - -
P70699 BXGT011681 Lysosomal alpha-glucosidase reviewed - Gaa EC50 '=' 98800 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA FC '=' 1 -
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 Inhibition '<' 50 %
P94451 BXGT012134 Alpha-amylase unreviewed - IC50 '=' 1670 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 500000 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 '=' 100000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '=' 506000 nM
P27034 BXGT009152 Beta-glucosidase reviewed - cbg-1 Ki '=' 12000 nM
Q2KIM0 BXGT014117 Tissue alpha-L-fucosidase reviewed - FUCA1 Inhibition '<' 50 %
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 36 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 65 nM
Q42656 BXGT014579 Alpha-galactosidase reviewed - IC50 '=' 23000 nM
Q13133 BXGT013315 Oxysterols receptor LXR-alpha reviewed Nuclear receptor NR1H3 IC50 '>' 100000 nM
P55055 BXGT011101 Oxysterols receptor LXR-beta reviewed Nuclear receptor NR1H2 IC50 '>' 100000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si Inhibition '=' 100 %
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '=' 240000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 400 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 - - -
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Ki '=' 21000 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Ki '=' 160 nM
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 '=' 30000 nM
O70282 BXGT005062 Trehalase unreviewed - IC50 - - -
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Ki '=' 23000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 210 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 1000 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 570000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 91900 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 1500 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Ki '=' 300000 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 1300 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Ki '=' 460000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Ki '=' 150 nM
P21139 BXGT008624 Alpha-mannosidase 2C1 reviewed - Man2c1 IC50 '<' 50000 nM
O00754 BXGT003944 Lysosomal alpha-mannosidase reviewed - MAN2B1 Inhibition '<' 50 %
O00462 BXGT003925 Beta-mannosidase reviewed Enzyme MANBA Inhibition '<' 50 %
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 Inhibition '<' 50 %
Q9H227 BXGT020447 Cytosolic beta-glucosidase reviewed Enzyme GBA3 IC50 '=' 80000 nM
Q9UUZ4 BXGT021832 Alpha-galactosidase C reviewed - aglC Inhibition '<' 50 %
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Activity - - -
Q2KHZ8 BXGT014115 Lysosomal acid glucosylceramidase reviewed - GBA Inhibition '<' 50 %
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 360 nM
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 - - -
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Inhibition '<' 50 %
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI Inhibition '=' 95 %
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Delta Tm '=' 0 degrees C
Q9LGC6 BXGT021076 Putative alpha-glucosidase unreviewed - P0504H10.9 IC50 '=' 50 nM
Q43014 BXGT014582 Beta-glucosidase unreviewed - Ki '=' 9500 nM
Q9MYM4 BXGT021111 Lysosomal alpha-glucosidase reviewed - GAA IC50 '=' 400 nM
P35574 BXGT009851 Glycogen debranching enzyme reviewed - AGL IC50 '=' 190 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 60 nM
Q9Y2E5 BXGT022231 Epididymis-specific alpha-mannosidase reviewed - MAN2B2 Inhibition '<' 50 %
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 320000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Delta Tm '=' 0 degrees C
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 IC50 '=' 110000 nM
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition - - -
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency - 51 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 210000 nM
Q8BVW0 BXGT017923 Neutral alpha-glucosidase C reviewed - Ganc IC50 - - -
Q9MYM4 BXGT021111 Lysosomal alpha-glucosidase reviewed - GAA IC50 '=' 21000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Inhibition '<' 50 %
I3LIR5 BXGT003674 Trehalase unreviewed - TREH IC50 '=' 41000 nM
O70282 BXGT005062 Trehalase unreviewed - IC50 '=' 42000 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 '=' 520000 nM
Q8BVW0 BXGT017923 Neutral alpha-glucosidase C reviewed - Ganc IC50 '=' 300 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 300 nM
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 IC50 '=' 30000 nM
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 IC50 '=' 278000 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Ki '=' 18000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '>' 300000 nM
Q6P4F1 BXGT016448 Alpha-(1,3)-fucosyltransferase 10 reviewed Enzyme FUT10 Relative activity '=' 5 -
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 '=' 27000 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '=' 360 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '>' 500000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si Ki '=' 24 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Ki '=' 47000 nM
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 IC50 '=' 26000 nM
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 Ki '>' 100000000 nM
Q4FZV0 BXGT014807 Beta-mannosidase reviewed - Manba Inhibition '<' 50 %
Q8BVW0 BXGT017923 Neutral alpha-glucosidase C reviewed - Ganc IC50 '=' 34000 nM
Q2KHZ8 BXGT014115 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '=' 210000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 1000000 nM
Q9MYM4 BXGT021111 Lysosomal alpha-glucosidase reviewed - GAA IC50 - - -
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 1000000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 650 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '=' 40 nM
Q9H227 BXGT020447 Cytosolic beta-glucosidase reviewed Enzyme GBA3 IC50 '=' 240000 nM
P16278 BXGT008213 Beta-galactosidase reviewed Enzyme GLB1 Inhibition '<' 50 %
Q9LGC6 BXGT021076 Putative alpha-glucosidase unreviewed - P0504H10.9 IC50 '=' 30 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '=' 118000 nM
P06720 BXGT006482 Alpha-galactosidase reviewed - melA Inhibition '<' 20 %
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Ki '=' 14 nM
P35573 BXGT009850 Glycogen debranching enzyme reviewed Enzyme AGL IC50 '=' 10000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Ki '=' 2000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 25000 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 '=' 55000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 100 nM
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 IC50 '=' 300000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 160 nM
Q9SEH8 BXGT021581 alpha-1,2-Mannosidase unreviewed - Man1 Inhibition '<' 50 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 15848 nM
O43280 BXGT004582 Trehalase reviewed - TREH IC50 '=' 40000 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB IC50 '=' 25000 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 560000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA IC50 '=' 195000 nM
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI IC50 '=' 2000 nM
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 IC50 '>' 1000000 nM
P10482 BXGT007574 Beta-glucosidase A reviewed - bglA IC50 '=' 460000 nM
P28494 BXGT009264 Alpha-mannosidase 2 reviewed - Man2a1 Ki '<' 50000 nM
Q02401 BXGT012651 Lactase-phlorizin hydrolase reviewed - Lct IC50 '=' 34000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Ki '=' 79000 nM
O70282 BXGT005062 Trehalase unreviewed - IC50 '=' 41000 nM
Q43014 BXGT014582 Beta-glucosidase unreviewed - Inhibition '=' 50 %
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 IC50 '=' 390000 nM
Q43014 BXGT014582 Beta-glucosidase unreviewed - IC50 '=' 81000 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Inhibition '=' 100 %
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Ki '=' 25000 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 39810 nM
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 IC50 '=' 21000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 360 nM
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 IC50 '=' 28800 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 130 nM
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 IC50 '=' 425600000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA FC '=' 4 -
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 Inhibition '<' 50 %
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 12589 nM
Q6P7A9 BXGT016460 Lysosomal alpha-glucosidase reviewed - Gaa IC50 '=' 150000 nM
Q02401 BXGT012651 Lactase-phlorizin hydrolase reviewed - Lct IC50 '=' 26000 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 510 nM
Q02401 BXGT012651 Lactase-phlorizin hydrolase reviewed - Lct IC50 '=' 49000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA FC '=' 2 -
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '=' 2000 nM
P09848 BXGT006929 Lactase-phlorizin hydrolase reviewed Enzyme LCT IC50 '=' 62000 nM
P53051 BXGT010971 Oligo-1,6-glucosidase IMA1 reviewed - IMA1 IC50 '=' 330000 nM
Q16739 BXGT013663 Ceramide glucosyltransferase reviewed Enzyme UGCG IC50 '>' 100000 nM
Q2M2H8 BXGT026100 Probable maltase-glucoamylase 2 reviewed Enzyme MGAM2 Inhibition - - -
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI Inhibition - - -
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Inhibition - - -
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Inhibition - - -
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Delta Tm '=' 2 degrees C
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Ki '=' 410000 nM
Q2M2H8 BXGT026100 Probable maltase-glucoamylase 2 reviewed Enzyme MGAM2 IC50 '=' 192000 nM
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI IC50 '=' 192000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 192000 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '=' 192000 nM
P28494 BXGT009264 Alpha-mannosidase 2 reviewed - Man2a1 IC50 '<' 50000 nM
Q6P762 BXGT016459 Alpha-mannosidase unreviewed - Man2b1 IC50 '=' 1000000 nM
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase reviewed - GBA2 IC50 '=' 20000 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Delta Tm '=' 1 degrees C
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Delta Tm '=' 0 degrees C
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 IC50 - - -
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Ki - - -
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition - - -
Q2M2H8 BXGT026100 Probable maltase-glucoamylase 2 reviewed Enzyme MGAM2 Ki - - -
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI Ki - - -
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Ki - - -
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Ki - - -
Q2M2H8 BXGT026100 Probable maltase-glucoamylase 2 reviewed Enzyme MGAM2 IC50 '=' 39500 nM
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI IC50 '=' 39500 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 39500 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM IC50 '=' 39500 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00845 Castanospermum australe Castanospermum australe Vegetables
BXGF02214 Morus bombycis Morus bombycis Medicinal Plant
BXGF03024 Taxillus chinensis Taxillus chinensis Human Edible Plant
BXGF03204 Xanthocercis zambesiaca Xanthocercis zambesiaca Others
BXGF04607 Morus alba Morus alba Medicinal Plant
BXGF05068 aglaonema treubii aglaonema treubii Others
BXGF06290 Cinnamosma macrocarpa Cinnamosma macrocarpa Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease