Showing entry for E3 ubiquitin-protein ligase SIAH2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004579
Protein NameE3 ubiquitin-protein ligase SIAH2
Uniport IdO43255
GeneSIAH2
Gene Id6478
DomainSina
Pfam PF03145  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007049 cell cycle
Biological Process GO:0044257 cellular protein catabolic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:1902842 negative regulation of netrin-activated signaling pathway
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0031396 regulation of protein ubiquitination
Biological Process GO:0048511 rhythmic process
Biological Process GO:0007264 small GTPase mediated signal transduction
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0003714 transcription corepressor activity
molecular function GO:0031624 ubiquitin conjugating enzyme binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0042025 host cell nucleus
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-373752 Netrin-1 signaling
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-9675108 Nervous system development
R-HSA-977225 Amyloid fiber formation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0023308 BXGD001632 Lens Diseases Eye Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0079680 BXGD003085 Lentivirus Infections Infections
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679427 BXGD009777 myeloblastosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein