Showing entry for Receptor activity-modifying protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004907
Protein NameReceptor activity-modifying protein 2
Uniport IdO60895
GeneRAMP2
Gene Id10266
DomainRAMP
Pfam PF04901  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0034333 adherens junction assembly
Biological Process GO:1990410 adrenomedullin receptor signaling pathway
Biological Process GO:0097647 amylin receptor signaling pathway
Biological Process GO:0001525 angiogenesis
Biological Process GO:0070831 basement membrane assembly
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0007565 female pregnancy
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007507 heart development
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:2001214 positive regulation of vasculogenesis
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0015031 protein transport
Biological Process GO:0031623 receptor internalization
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0008277 regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0032355 response to estradiol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032570 response to progesterone
Biological Process GO:0002040 sprouting angiogenesis
Biological Process GO:0097084 vascular associated smooth muscle cell development
Biological Process GO:0001570 vasculogenesis
molecular function GO:1990409 adrenomedullin binding
molecular function GO:0001605 adrenomedullin receptor activity
molecular function GO:0015026 coreceptor activity
cellular component GO:1903143 adrenomedullin receptor complex
cellular component GO:0150057 amylin receptor complex 2
cellular component GO:0009986 cell surface
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0005737 cytoplasm
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005764 lysosome
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0007097 BXGD000424 Carcinoma Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024814 BXGD001809 Marinesco-Sjogren syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038187 BXGD002737 Starvation Nutritional and Metabolic Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0043094 BXGD003026 Weight Gain Pathological Conditions, Signs and Symptoms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0154841 BXGD003749 Central retinal vein occlusion Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0205641 BXGD004093 Adenocarcinoma, Basal Cell Neoplasms
C0205642 BXGD004094 Adenocarcinoma, Oxyphilic Neoplasms
C0205643 BXGD004095 Carcinoma, Cribriform Neoplasms
C0205644 BXGD004096 Carcinoma, Granular Cell Neoplasms
C0205645 BXGD004097 Adenocarcinoma, Tubular Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265116 BXGD005457 Chronic cerebral ischemia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0280781 BXGD006758 Adult Pilocytic Astrocytoma Neoplasms
C0334583 BXGD007124 Pilocytic Astrocytoma Neoplasms
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0852036 BXGD010934 Pregnancy associated hypertension Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0860659 BXGD011240 Aloof
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1332995 BXGD012575 Childhood Pilocytic Astrocytoma Neoplasms
C1395512 BXGD012989 Placental dysfunction
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein