adisease

Showing entry for Pediatric Obesity

General Disease Information
BXGD Id	BXGD017091
Disease Name	Pediatric Obesity
Disease CUI Id	C2362324
MeSH Codes	C23 C18
Disease Class Name	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O00763	BXGT003947	Acetyl-CoA carboxylase 2	32	reviewed
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O60240	BXGT004860	Perilipin-1	5346	reviewed
O60895	BXGT004907	Receptor activity-modifying protein 2	10266	reviewed	Receptor
O75715	BXGT005146	Epididymal secretory glutathione peroxidase	2880	reviewed	Enzyme
O95237	BXGT005361	Lecithin retinol acyltransferase	9227	reviewed
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
P00156	BXGT005469	Cytochrome b	4519	reviewed
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P00846	BXGT005674	ATP synthase subunit a	4508	reviewed	Transporter
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04745	BXGT006255	Alpha-amylase 1	278	reviewed
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P11597	BXGT007727	Cholesteryl ester transfer protein	1071	reviewed
P12268	BXGT007783	Inosine-5'-monophosphate dehydrogenase 2	3615	reviewed	Enzyme
P13945	BXGT007972	Beta-3 adrenergic receptor	155	reviewed	G-protein coupled receptor
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	2167	reviewed
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P17707	BXGT008331	S-adenosylmethionine decarboxylase proenzyme	262	reviewed	Enzyme
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21953	BXGT008711	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	594	reviewed	Enzyme
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30559	BXGT009442	Oxytocin receptor	5021	reviewed	G-protein coupled receptor
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P32245	BXGT009614	Melanocortin receptor 4	4160	reviewed	G-protein coupled receptor
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P35558	BXGT009847	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	5105	reviewed	Kinase
P36969	BXGT009949	Phospholipid hydroperoxide glutathione peroxidase	2879	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41968	BXGT010275	Melanocortin receptor 3	4159	reviewed	G-protein coupled receptor
P43490	BXGT010395	Nicotinamide phosphoribosyltransferase	10135	reviewed	Signaling
P48029	BXGT010606	Sodium- and chloride-dependent creatine transporter 1	6535	reviewed	Transporter
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48546	BXGT010642	Gastric inhibitory polypeptide receptor	2696	reviewed	G-protein coupled receptor
P49146	BXGT010681	Neuropeptide Y receptor type 2	4887	reviewed	G-protein coupled receptor
P49286	BXGT010691	Melatonin receptor type 1B	4544	reviewed	G-protein coupled receptor
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P51449	BXGT010846	Nuclear receptor ROR-gamma	6097	reviewed	Nuclear receptor
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P59796	BXGT011278	Glutathione peroxidase 6	257202	reviewed	Enzyme
P62070	BXGT011404	Ras-related protein R-Ras2	22800	reviewed	Enzyme modulator
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q13163	BXGT013321	Dual specificity mitogen-activated protein kinase kinase 5	5607	reviewed	Kinase
Q13332	BXGT013342	Receptor-type tyrosine-protein phosphatase S	5802	reviewed	Enzyme
Q14397	BXGT013467	Glucokinase regulatory protein	2646	reviewed
Q14624	BXGT013491	Inter-alpha-trypsin inhibitor heavy chain H4	3700	reviewed	Enzyme modulator
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q59H18	BXGT015278	Serine/threonine-protein kinase TNNI3K	51086	reviewed
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q687X5	BXGT016184	Metalloreductase STEAP4	79689	reviewed
Q92932	BXGT019395	Receptor-type tyrosine-protein phosphatase N2	5799	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96PR1	BXGT019710	Potassium voltage-gated channel subfamily C member 2	3747	reviewed	Ion channel
Q96PU5	BXGT019711	E3 ubiquitin-protein ligase NEDD4-like	23327	reviewed	Enzyme
Q99523	BXGT019929	Sortilin	6272	reviewed	Transporter
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9UBE8	BXGT021652	Serine/threonine-protein kinase NLK	51701	reviewed	Kinase
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
O14520	BXGT024716	Aquaporin-7	364	reviewed	Ion channel
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}