Showing entry for Pro-cathepsin H


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006914
Protein NamePro-cathepsin H
Uniport IdP09668
GeneCTSH
Gene Id1512
DomainInhibitor_I29; Peptidase_C1
Pfam PF08246   PF00112  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0019882 antigen processing and presentation
Biological Process GO:0010815 bradykinin catabolic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0097067 cellular response to thyroid hormone stimulus
Biological Process GO:0060448 dichotomous subdivision of terminal units involved in lung branching
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0002764 immune response-regulating signaling pathway
Biological Process GO:0033619 membrane protein proteolysis
Biological Process GO:0001656 metanephros development
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0010813 neuropeptide catabolic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:2001235 positive regulation of apoptotic signaling pathway
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0010952 positive regulation of peptidase activity
Biological Process GO:0031648 protein destabilization
Biological Process GO:0006508 proteolysis
Biological Process GO:0051603 proteolysis involved in cellular protein catabolic process
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0043129 surfactant homeostasis
Biological Process GO:0001913 T cell mediated cytotoxicity
Biological Process GO:0031638 zymogen activation
molecular function GO:0004177 aminopeptidase activity
molecular function GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0008234 cysteine-type peptidase activity
molecular function GO:0004175 endopeptidase activity
molecular function GO:0030108 HLA-A specific activating MHC class I receptor activity
molecular function GO:0008233 peptidase activity
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0070324 thyroid hormone binding
cellular component GO:0097208 alveolar lamellar body
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005764 lysosome
cellular component GO:0097486 multivesicular body lumen
cellular component GO:0034774 secretory granule lumen
cellular component GO:1904724 tertiary granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2132295 MHC class II antigen presentation
R-HSA-392499 Metabolism of proteins
R-HSA-5683826 Surfactant metabolism
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007117 BXGD000433 Basal cell carcinoma Neoplasms
C0007384 BXGD000463 Cataplexy Nervous System Diseases; Mental Disorders
C0008373 BXGD000536 Cholesteatoma Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027092 BXGD001971 Myopia Eye Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0037316 BXGD002688 Sleep Deprivation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0153685 BXGD003682 Secondary malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0154830 BXGD003746 Proliferative diabetic retinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200635 BXGD004041 Lymphocyte Count measurement
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206710 BXGD004258 Basal Cell Neoplasm Neoplasms
C0234518 BXGD004683 Slurred speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0338591 BXGD007204 Amnesia, Transient Global Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0342302 BXGD007458 Brittle diabetes Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392188 BXGD008036 Abnormal rapid eye movement sleep Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0751362 BXGD010411 Narcolepsy-Cataplexy Syndrome Nervous System Diseases; Mental Disorders
C0751676 BXGD010549 Basal Cell Cancer Neoplasms
C1168327 BXGD011787 High-Grade Prostatic Intraepithelial Neoplasia Neoplasms; Male Urogenital Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1861028 BXGD016010 Esophageal atresia with or without tracheoesophageal fistula Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C3837958 BXGD019756 Diabetes Mellitus, Ketosis-Prone Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C4025846 BXGD021826 Abnormality of vision
C4551761 BXGD023405 Excessive daytime sleepiness
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4554117 BXGD023561 Diabetes Mellitus, Sudden-Onset Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0013414 Trehalose 342.12
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein