Showing entry for Polyubiquitin-C



                       
General Target Information
BXGT IdBXGT007468
Protein NamePolyubiquitin-C
Uniport IdP0CG48
GeneUBC
Gene Id7316
Domainubiquitin
Pfam PF00240  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0016197 endosomal transport
Biological Process GO:0070987 error-free translesion synthesis
Biological Process GO:0042276 error-prone translesion synthesis
Biological Process GO:0070911 global genome nucleotide-excision repair
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0075733 intracellular transport of virus
Biological Process GO:0007254 JNK cascade
Biological Process GO:0061024 membrane organization
Biological Process GO:0019941 modification-dependent protein catabolic process
Biological Process GO:0002755 MyD88-dependent toll-like receptor signaling pathway
Biological Process GO:0002756 MyD88-independent toll-like receptor signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
Biological Process GO:0000715 nucleotide-excision repair, DNA damage recognition
Biological Process GO:0000717 nucleotide-excision repair, DNA duplex unwinding
Biological Process GO:0006297 nucleotide-excision repair, DNA gap filling
Biological Process GO:0033683 nucleotide-excision repair, DNA incision
Biological Process GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
Biological Process GO:0006294 nucleotide-excision repair, preincision complex assembly
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0051403 stress-activated MAPK cascade
Biological Process GO:0006283 transcription-coupled nucleotide-excision repair
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0019985 translesion synthesis
Biological Process GO:0055085 transmembrane transport
Biological Process GO:0035666 TRIF-dependent toll-like receptor signaling pathway
Biological Process GO:0019058 viral life cycle
Biological Process GO:0019068 virion assembly
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0002020 protease binding
molecular function GO:0031386 protein tag
molecular function GO:0003723 RNA binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0043657 host cell
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-110312 Translesion synthesis by REV1
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110320 Translesion Synthesis by POLH
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1227986 Signaling by ERBB2
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1236394 Signaling by ERBB4
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1253288 Downregulation of ERBB4 signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-HSA-1430728 Metabolism
R-HSA-157118 Signaling by NOTCH
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-162587 HIV Life Cycle
R-HSA-162588 Budding and maturation of HIV virion
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1632852 Macroautophagy
R-HSA-1632852 Macroautophagy
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-169911 Regulation of Apoptosis
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins
R-HSA-175474 Assembly Of The HIV Virion
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-177929 Signaling by EGFR
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-182971 EGFR downregulation
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-190236 Signaling by FGFR
R-HSA-193639 p75NTR signals via NF-kB
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195721 Signaling by WNT
R-HSA-1980143 Signaling by NOTCH1
R-HSA-1980143 Signaling by NOTCH1
R-HSA-1980145 Signaling by NOTCH2
R-HSA-199991 Membrane Trafficking
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-205043 NRIF signals cell death from the nucleus
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-2262752 Cellular responses to stress
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559583 Cellular Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2672351 Stimuli-sensing channels
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3229121 Glycogen storage diseases
R-HSA-3322077 Glycogen synthesis
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-376176 Signaling by ROBO receptors
R-HSA-376176 Signaling by ROBO receptors
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-3785653 Myoclonic epilepsy of Lafora
R-HSA-382551 Transport of small molecules
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-400253 Circadian Clock
R-HSA-4086400 PCP/CE pathway
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446652 Interleukin-1 family signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-4641263 Regulation of FZD by ubiquitination
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5205647 Mitophagy
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218859 Regulated Necrosis
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-5357801 Programmed Cell Death
R-HSA-5357801 Programmed Cell Death
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5619084 ABC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-5655862 Translesion synthesis by POLK
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5663084 Diseases of carbohydrate metabolism
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5668914 Diseases of metabolism
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5675482 Regulation of necroptotic cell death
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5688426 Deubiquitination
R-HSA-5688426 Deubiquitination
R-HSA-5689603 UCH proteinases
R-HSA-5689603 UCH proteinases
R-HSA-5689877 Josephin domain DUBs
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-5689901 Metalloprotease DUBs
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6804760 Regulation of TP53 Activity through Methylation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-6806834 Signaling by MET
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6807070 PTEN Regulation
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69206 G1/S Transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69236 G1 Phase
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69481 G2/M Checkpoints
R-HSA-69541 Stabilization of p53
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-69610 p53-Independent DNA Damage Response
R-HSA-69613 p53-Independent G1/S DNA damage checkpoint
R-HSA-69615 G1/S DNA Damage Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-71387 Metabolism of carbohydrates
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73887 Death Receptor Signalling
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
R-HSA-75893 TNF signaling
R-HSA-8848021 Signaling by PTK6
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-HSA-8852135 Protein ubiquitination
R-HSA-8852135 Protein ubiquitination
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8948747 Regulation of PTEN localization
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8982491 Glycogen metabolism
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
R-HSA-901032 ER Quality Control Compartment (ERQC)
R-HSA-901042 Calnexin/calreticulin cycle
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013694 Signaling by NOTCH4
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9020702 Interleukin-1 signaling
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033241 Peroxisomal protein import
R-HSA-912631 Regulation of signaling by CBL
R-HSA-913531 Interferon Signaling
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-917937 Iron uptake and transport
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937039 IRAK1 recruits IKK complex
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937042 IRAK2 mediated activation of TAK1 complex
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
R-HSA-9612973 Autophagy
R-HSA-9612973 Autophagy
R-HSA-9613829 Chaperone Mediated Autophagy
R-HSA-9615710 Late endosomal microautophagy
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-9636383 Prevention of phagosomal-lysosomal fusion
R-HSA-9637628 Modulation by Mtb of host immune system
R-HSA-9637687 Suppression of phagosomal maturation
R-HSA-9637690 Response of Mtb to phagocytosis
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway
R-HSA-9646399 Aggrephagy
R-HSA-9646399 Aggrephagy
R-HSA-9648002 RAS processing
R-HSA-9663891 Selective autophagy
R-HSA-9663891 Selective autophagy
R-HSA-9664873 Pexophagy
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9683683 Maturation of protein E
R-HSA-9683701 Translation of structural proteins
R-HSA-9694493 Maturation of protein E
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694635 Translation of structural proteins
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-977225 Amyloid fiber formation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005694 BXGD000322 Bladder neck obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023804 BXGD001704 Lipomatosis, Multiple Symmetrical Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027873 BXGD002054 Neuromyelitis Optica Eye Diseases; Immune System Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036161 BXGD002580 Sandhoff Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0158252 BXGD003877 Intervertebral disc disorder Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206630 BXGD004195 Endometrial Stromal Sarcoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0338113 BXGD007168 Uterine Corpus Sarcoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349636 BXGD007941 Pre B-cell acute lymphoblastic leukemia
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751967 BXGD010657 Multiple Sclerosis, Relapsing-Remitting Immune System Diseases; Nervous System Diseases
C0752304 BXGD010711 Hypoxic-Ischemic Encephalopathy Nervous System Diseases; Cardiovascular Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334953 BXGD012746 Neuroblastic tumors Neoplasms
C1370723 BXGD012916 Stromal sarcoma
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4082769 BXGD022094 Chronic Traumatic Encephalopathy Nervous System Diseases; Wounds and Injuries
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000696 Tartaric acid 150.09
BXGC0002401 Ethanamine 45.08
BXGC0002588 Magnesium 24.31
BXGC0002692 Arsenic 77.95
BXGC0002722 Nitrate 62
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0005937 1-Propylamine 59.11
BXGC0006368 Formic acid 46.03
BXGC0014659 D-Alanine 89.05
BXGC0030612 tetraethylene glycol 194.12
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein