adisease

Showing entry for Lewy Body Disease

General Disease Information
BXGD Id	BXGD010721
Disease Name	Lewy Body Disease
Disease CUI Id	C0752347
MeSH Codes	C10 F03
Disease Class Name	Nervous System Diseases; Mental Disorders
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00459	BXGT003924	Phosphatidylinositol 3-kinase regulatory subunit beta	5296	reviewed	Enzyme modulator
O14578	BXGT004072	Citron Rho-interacting kinase	11113	reviewed	Kinase
O15392	BXGT004162	Baculoviral IAP repeat-containing protein 5	332	reviewed	Enzyme modulator
O43464	BXGT004595	Serine protease HTRA2, mitochondrial	27429	reviewed
O43765	BXGT004621	Small glutamine-rich tetratricopeptide repeat-containing protein alpha	6449	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O75628	BXGT005140	GTP-binding protein REM 1	28954	reviewed
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P03951	BXGT006117	Coagulation factor XI	2160	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05413	BXGT006355	Fatty acid-binding protein, heart	2170	reviewed
P05937	BXGT006396	Calbindin	793	reviewed	Calcium-binding protein
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P06276	BXGT006430	Cholinesterase	590	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07478	BXGT006630	Trypsin-2	5645	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08559	BXGT006788	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	5160	reviewed
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P0CG47	BXGT007467	Polyubiquitin-B	7314	reviewed	Nucleic acid binding
P0CG48	BXGT007468	Polyubiquitin-C	7316	reviewed	Nucleic acid binding
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10909	BXGT007630	Clusterin	1191	reviewed
P11137	BXGT007656	Microtubule-associated protein 2	4133	reviewed
P11717	BXGT007740	Cation-independent mannose-6-phosphate receptor	3482	reviewed	Receptor
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14616	BXGT008026	Insulin receptor-related protein	3645	reviewed	Kinase
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15374	BXGT008113	Ubiquitin carboxyl-terminal hydrolase isozyme L3	7347	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16157	BXGT008203	Ankyrin-1	286	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P25098	BXGT009015	Beta-adrenergic receptor kinase 1	156	reviewed	Kinase
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P29218	BXGT009322	Inositol monophosphatase 1	3612	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30536	BXGT009435	Translocator protein	706	reviewed
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P31947	BXGT009589	14-3-3 protein sigma	2810	reviewed	Chaperone
P34913	BXGT009770	Bifunctional epoxide hydrolase 2	2053	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P34947	BXGT009774	G protein-coupled receptor kinase 5	2869	reviewed	Kinase
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36544	BXGT009926	Neuronal acetylcholine receptor subunit alpha-7	89832	reviewed
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42575	BXGT010318	Caspase-2	835	reviewed	Enzyme
P43004	BXGT010348	Excitatory amino acid transporter 2	6506	reviewed	Transporter
P43354	BXGT010381	Nuclear receptor subfamily 4 group A member 2	4929	reviewed	Nuclear receptor
P43652	BXGT010405	Afamin	173	reviewed	Transporter
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P48740	BXGT010659	Mannan-binding lectin serine protease 1	5648	reviewed	Enzyme
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49810	BXGT010747	Presenilin-2	5664	reviewed	Enzyme
P52758	BXGT010951	2-iminobutanoate/2-iminopropanoate deaminase	10247	reviewed
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P56817	BXGT011200	Beta-secretase 1	23621	reviewed	Enzyme
P62942	BXGT011474	Peptidyl-prolyl cis-trans isomerase FKBP1A	2280	reviewed	Enzyme
P62979	BXGT011476	Ubiquitin-40S ribosomal protein S27a	6233	reviewed	Nucleic acid binding
P68104	BXGT011575	Elongation factor 1-alpha 1	1915	reviewed	Enzyme
P78330	BXGT011833	Phosphoserine phosphatase	5723	reviewed	Enzyme
P78352	BXGT011836	Disks large homolog 4	1742	reviewed	Receptor
Q00059	BXGT012512	Transcription factor A, mitochondrial	7019	reviewed
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q04637	BXGT012771	Eukaryotic translation initiation factor 4 gamma 1	1981	reviewed	Nucleic acid binding
Q07817	BXGT012941	Bcl-2-like protein 1	598	reviewed	Signaling
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q13427	BXGT013354	Peptidyl-prolyl cis-trans isomerase G	9360	reviewed
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13510	BXGT013367	Acid ceramidase	427	reviewed	Enzyme
Q13627	BXGT013385	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	1859	reviewed	Kinase
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q16620	BXGT013645	BDNF/NT-3 growth factors receptor	4915	reviewed	Kinase
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5SRE7	BXGT015840	Phytanoyl-CoA dioxygenase domain-containing protein 1	254295	reviewed
Q92876	BXGT019388	Kallikrein-6	5653	reviewed	Enzyme
Q99497	BXGT019926	Protein/nucleic acid deglycase DJ-1	11315	reviewed	Enzyme
Q99653	BXGT019945	Calcineurin B homologous protein 1	11261	reviewed
Q9BXM7	BXGT020172	Serine/threonine-protein kinase PINK1, mitochondrial	65018	reviewed	Kinase
Q9NQX4	BXGT021173	Unconventional myosin-Vc	55930	reviewed	Cellular structure
Q9NYY3	BXGT021264	Serine/threonine-protein kinase PLK2	10769	reviewed	Kinase
Q9P2R7	BXGT021304	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	8803	reviewed	Enzyme
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9UQM7	BXGT021814	Calcium/calmodulin-dependent protein kinase type II subunit alpha	815	reviewed	Kinase
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
P09622	BXGT023116	Dihydrolipoyl dehydrogenase, mitochondrial	1738	reviewed	Enzyme
O60502	BXGT023392	Protein O-GlcNAcase	10724	reviewed
Q96DA2	BXGT025522	Ras-related protein Rab-39B	116442	reviewed
Q96Q15	BXGT025610	Serine/threonine-protein kinase SMG1	23049	reviewed	Kinase
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}