Showing entry for Arachidonate 5-lipoxygenase-activating protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008561
Protein NameArachidonate 5-lipoxygenase-activating protein
Uniport IdP20292
GeneALOX5AP
Gene Id241
DomainMAPEG
Pfam PF01124  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0019370 leukotriene biosynthetic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:2001301 lipoxin biosynthetic process
Biological Process GO:0019372 lipoxygenase pathway
Biological Process GO:0070207 protein homotrimerization
molecular function GO:0050544 arachidonic acid binding
molecular function GO:0008047 enzyme activator activity
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0004364 glutathione transferase activity
molecular function GO:0004464 leukotriene-C4 synthase activity
molecular function GO:0047485 protein N-terminus binding
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005635 nuclear envelope
cellular component GO:0031965 nuclear membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142700 Synthesis of Lipoxins (LX)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024441 BXGD001775 Macular Holes Eye Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035321 BXGD002536 Retinal Perforations Eye Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149504 BXGD003322 Encephalopathy, Toxic Nervous System Diseases; Chemically-Induced Disorders
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154659 BXGD003725 Toxic Encephalitis Nervous System Diseases; Chemically-Induced Disorders
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0231926 BXGD004531 Ventilatory defect Respiratory Tract Diseases
C0235032 BXGD004715 Neurotoxicity Syndromes Nervous System Diseases; Chemically-Induced Disorders
C0242129 BXGD005136 Thrombotic stroke Nervous System Diseases; Cardiovascular Diseases
C0242706 BXGD005191 Hyperoxia Pathological Conditions, Signs and Symptoms
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0543699 BXGD009293 ASA intolerant asthma Respiratory Tract Diseases; Immune System Diseases
C0578870 BXGD009553 Chronic idiopathic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751010 BXGD010289 Cerebral Infarction, Left Hemisphere Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751011 BXGD010290 Cerebral Infarction, Right Hemisphere Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751012 BXGD010291 Anterior Choroidal Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751014 BXGD010292 Subcortical Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0887799 BXGD011396 Posterior Choroidal Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1563937 BXGD013397 Atherogenesis Cardiovascular Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C3822559 BXGD019674 response to epirubicin
C3845502 BXGD019809 Myocardial infarction, stroke
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005984 Psoralidin 336.34
BXGC0012243 Ukonan D 151.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein