adisease

Showing entry for Scleroderma

General Disease Information
BXGD Id	BXGD000744
Disease Name	Scleroderma
Disease CUI Id	C0011644
MeSH Codes	C17
Disease Class Name	Skin and Connective Tissue Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001574
Human Phenotype Ontology Term	Abnormality of the integument
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00469	BXGT003926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	5352	reviewed	Enzyme
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14763	BXGT004093	Tumor necrosis factor receptor superfamily member 10B	8795	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43557	BXGT004600	Tumor necrosis factor ligand superfamily member 14	8740	reviewed	Signaling
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
O75914	BXGT005165	Serine/threonine-protein kinase PAK 3	5063	reviewed	Kinase
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95255	BXGT005363	Multidrug resistance-associated protein 6	368	reviewed	Transporter
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06756	BXGT006499	Integrin alpha-V	3685	reviewed
P07093	BXGT006544	Glia-derived nexin	5270	reviewed	Enzyme modulator
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08648	BXGT006804	Integrin alpha-5	3678	reviewed
P08700	BXGT006816	Interleukin-3	3562	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14207	BXGT007993	Folate receptor beta	2350	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16070	BXGT008186	CD44 antigen	960	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P20292	BXGT008561	Arachidonate 5-lipoxygenase-activating protein	241	reviewed	Enzyme
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21580	BXGT008666	Tumor necrosis factor alpha-induced protein 3	7128	reviewed	Enzyme
P21583	BXGT008667	Kit ligand	4254	reviewed
P21709	BXGT008685	Ephrin type-A receptor 1	2041	reviewed	Kinase
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22087	BXGT008729	rRNA 2'-O-methyltransferase fibrillarin	2091	reviewed	Enzyme
P24158	BXGT008951	Myeloblastin	5657	reviewed	Enzyme
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P25713	BXGT009062	Metallothionein-3	4504	reviewed
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P36871	BXGT009936	Phosphoglucomutase-1	5236	reviewed
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49450	BXGT010710	Histone H3-like centromeric protein A	1058	reviewed
P49747	BXGT010732	Cartilage oligomeric matrix protein	1311	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P52952	BXGT010966	Homeobox protein Nkx-2.5	1482	reviewed	Transcription factor
P54132	BXGT011032	Bloom syndrome protein	641	reviewed
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P55809	BXGT011127	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	5019	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P62942	BXGT011474	Peptidyl-prolyl cis-trans isomerase FKBP1A	2280	reviewed	Enzyme
P78362	BXGT011839	SRSF protein kinase 2	6733	reviewed	Kinase
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P99999	BXGT012235	Cytochrome c	54205	reviewed
Q01780	BXGT012614	Exosome component 10	5394	reviewed
Q03405	BXGT012713	Urokinase plasminogen activator surface receptor	5329	reviewed
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13427	BXGT013354	Peptidyl-prolyl cis-trans isomerase G	9360	reviewed
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13822	BXGT013396	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	5168	reviewed	Enzyme
Q13873	BXGT013398	Bone morphogenetic protein receptor type-2	659	reviewed	Kinase
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15722	BXGT013590	Leukotriene B4 receptor 1	1241	reviewed	G-protein coupled receptor
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16666	BXGT013654	Gamma-interferon-inducible protein 16	3428	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16832	BXGT013678	Discoidin domain-containing receptor 2	4921	reviewed	Kinase
Q30154	BXGT014296	HLA class II histocompatibility antigen, DR beta 5 chain	3127	reviewed	Immune response
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92956	BXGT019399	Tumor necrosis factor receptor superfamily member 14	8764	reviewed
Q92979	BXGT019402	Ribosomal RNA small subunit methyltransferase NEP1	10436	reviewed	Nucleic acid binding
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q9BXA7	BXGT020164	Testis-specific serine/threonine-protein kinase 1	83942	reviewed	Kinase
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HCE7	BXGT020532	E3 ubiquitin-protein ligase SMURF1	57154	reviewed	Enzyme
Q9UQL6	BXGT021813	Histone deacetylase 5	10014	reviewed	Epigenetic regulator
Q9Y263	BXGT022220	Phospholipase A-2-activating protein	9373	reviewed	Enzyme modulator
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y4K0	BXGT022280	Lysyl oxidase homolog 2	4017	reviewed
Q9Y600	BXGT022311	Cysteine sulfinic acid decarboxylase	51380	reviewed	Enzyme
Q9Y657	BXGT022318	Spindlin-1	10927	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
P31994	BXGT023298	Low affinity immunoglobulin gamma Fc region receptor II-b	2213	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9HAU4	BXGT024040	E3 ubiquitin-protein ligase SMURF2	64750	reviewed	Enzyme
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P25090	BXGT025102	N-formyl peptide receptor 2	2358	reviewed	G-protein coupled receptor
Q96Q15	BXGT025610	Serine/threonine-protein kinase SMG1	23049	reviewed	Kinase
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}