Showing entry for 4-hydroxyphenylpyruvate dioxygenase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009664
Protein Name4-hydroxyphenylpyruvate dioxygenase
Uniport IdP32754
GeneHPD
Gene Id3242
DomainGlyoxalase
Pfam PF00903  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00350 Tyrosine metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00360 Phenylalanine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006559 L-phenylalanine catabolic process
Biological Process GO:0006572 tyrosine catabolic process
molecular function GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0000139 Golgi membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-8963684 Tyrosine catabolism
R-HSA-8963691 Phenylalanine and tyrosine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002873 BXGD000133 Anemia of chronic disease Hemic and Lymphatic Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008677 BXGD000560 Bronchitis, Chronic Infections; Respiratory Tract Diseases
C0011389 BXGD000718 Dental Plaque Stomatognathic Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014078 BXGD000890 Venezuelan equine encephalomyelitis Infections; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024205 BXGD001744 Lymphadenitis Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030524 BXGD002236 Paratuberculosis Infections; Animal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041309 BXGD002904 Tuberculosis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0041318 BXGD002909 Tuberculosis, Meningeal Infections; Nervous System Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042693 BXGD002996 Violence
C0080233 BXGD003110 Tooth Loss Stomatognathic Diseases
C0085568 BXGD003184 Buruli Ulcer Infections; Skin and Connective Tissue Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0151332 BXGD003415 Active tuberculosis Infections
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220697 BXGD004324 POLYDACTYLY, POSTAXIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220769 BXGD004343 FG syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nervous System Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0221074 BXGD004388 Depression, Postpartum Female Urogenital Diseases and Pregnancy Complications; Mental Disorders
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265220 BXGD005469 Pallister-Hall syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Nervous System Diseases
C0265306 BXGD005509 Greig cephalopolysyndactyly syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0268483 BXGD005959 Tyrosinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268487 BXGD005961 Tyrosine Transaminase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268490 BXGD005962 Tyrosinemia, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268623 BXGD006013 Tyrosinemia, Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345354 BXGD007728 Radial polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376338 BXGD007990 Diagnosis, Psychiatric Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0406161 BXGD008328 Seed corn Skin and Connective Tissue Diseases
C0423867 BXGD008517 Fine hair
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751435 BXGD010440 Hyperphenylalaninaemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0877008 BXGD011325 Enzyme inhibition disorder
C0920652 BXGD011472 skin irritant
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C1611743 BXGD013456 Familial (FPAH)
C1654637 BXGD013484 androgen independent prostate cancer
C1696701 BXGD013503 Skin-picking Behavior and Behavior Mechanisms
C1837770 BXGD014270 Sparse hair
C1848678 BXGD014964 4-Hydroxyphenylpyruvic aciduria
C1848680 BXGD014965 4-hydroxyphenylacetic aciduria Digestive System Diseases
C1851920 BXGD015246 Dopa-Responsive Dystonia Nervous System Diseases
C1879362 BXGD016576 Hypertyrosinemia
C2062441 BXGD016897 Influenza A
C2931042 BXGD017946 Hawkinsinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C3249881 BXGD018583 Infection - suppurative Pathological Conditions, Signs and Symptoms; Infections
C3495798 BXGD019003 Periodontal inflammation
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021780 BXGD020775 Abnormality of the liver
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4554601 BXGD023566 Amyloidosis cutis dyschromia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein