Showing entry for Spastic Paraplegia, Hereditary


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002704
Disease NameSpastic Paraplegia, Hereditary
Disease CUI IdC0037773
MeSH Codes C16   C10  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00189 BXGT003891 AP-4 complex subunit mu-1 9179 reviewed Extracellular structure
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O43896 BXGT004632 Kinesin-like protein KIF1C 10749 reviewed Cellular structure
P00846 BXGT005674 ATP synthase subunit a 4508 reviewed Transporter
P04004 BXGT006125 Vitronectin 7448 reviewed
P04350 BXGT006193 Tubulin beta-4A chain 10382 reviewed Cellular structure
P05023 BXGT006294 Sodium/potassium-transporting ATPase subunit alpha-1 476 reviewed Transporter
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P16389 BXGT008221 Potassium voltage-gated channel subfamily A member 2 3737 reviewed Ion channel
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P30044 BXGT009395 Peroxiredoxin-5, mitochondrial 25824 reviewed
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P33176 BXGT009699 Kinesin-1 heavy chain 3799 reviewed Cellular structure
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P49902 BXGT010758 Cytosolic purine 5'-nucleotidase 22978 reviewed Enzyme
P54762 BXGT011076 Ephrin type-B receptor 1 2047 reviewed Kinase
P54886 BXGT011092 Delta-1-pyrroline-5-carboxylate synthase 5832 reviewed Enzyme
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P61604 BXGT011380 10 kDa heat shock protein, mitochondrial 3336 reviewed Chaperone
Q12756 BXGT013261 Kinesin-like protein KIF1A 547 reviewed Cellular structure
Q12840 BXGT013269 Kinesin heavy chain isoform 5A 3798 reviewed Cellular structure
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q16595 BXGT013643 Frataxin, mitochondrial 2395 reviewed Enzyme
Q6XUX3 BXGT016612 Dual serine/threonine and tyrosine protein kinase 25778 reviewed Kinase
Q8TD30 BXGT018805 Alanine aminotransferase 2 84706 reviewed Enzyme
Q8WXF7 BXGT019011 Atlastin-1 51062 reviewed Enzyme modulator
Q96GD0 BXGT019665 Pyridoxal phosphate phosphatase 57026 reviewed Enzyme
Q99447 BXGT019922 Ethanolamine-phosphate cytidylyltransferase 5833 reviewed Enzyme
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q9C005 BXGT020207 Protein dpy-30 homolog 84661 reviewed
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase 57704 reviewed
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NZ09 BXGT021267 Ubiquitin-associated protein 1 51271 reviewed
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
Q9UBP0 BXGT023601 Spastin 6683 reviewed Cellular structure
Q9Y4W6 BXGT025025 AFG3-like protein 2 10939 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease