adisease

Showing entry for Brain atrophy

General Disease Information
BXGD Id	BXGD023362
Disease Name	Brain atrophy
Disease CUI Id	C4551584
MeSH Codes	C10
Disease Class Name	Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00189	BXGT003891	AP-4 complex subunit mu-1	9179	reviewed	Extracellular structure
O14773	BXGT004096	Tripeptidyl-peptidase 1	1200	reviewed	Enzyme
O15379	BXGT004159	Histone deacetylase 3	8841	reviewed	Epigenetic regulator
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O43424	BXGT004592	Glutamate receptor ionotropic, delta-2	2895	reviewed	Ion channel
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60706	BXGT004896	ATP-binding cassette sub-family C member 9	10060	reviewed	Transporter
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75306	BXGT005108	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	4720	reviewed	Enzyme
O76039	BXGT005171	Cyclin-dependent kinase-like 5	6792	reviewed	Kinase
O95278	BXGT005370	Laforin	7957	reviewed
O95970	BXGT005409	Leucine-rich glioma-inactivated protein 1	9211	reviewed
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05165	BXGT006334	Propionyl-CoA carboxylase alpha chain, mitochondrial	5095	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09651	BXGT006913	Heterogeneous nuclear ribonucleoprotein A1	3178	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10909	BXGT007630	Clusterin	1191	reviewed
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13688	BXGT007943	Carcinoembryonic antigen-related cell adhesion molecule 1	634	reviewed
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14550	BXGT008019	Aldo-keto reductase family 1 member A1	10327	reviewed	Enzyme
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P15151	BXGT008089	Poliovirus receptor	5817	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P19404	BXGT008477	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	4729	reviewed
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22626	BXGT008787	Heterogeneous nuclear ribonucleoproteins A2/B1	3181	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P27708	BXGT009202	CAD protein	790	reviewed	Enzyme
P28331	BXGT009252	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	4719	reviewed	Enzyme
P28676	BXGT009284	Grancalcin	25801	reviewed
P30536	BXGT009435	Translocator protein	706	reviewed
P33176	BXGT009699	Kinesin-1 heavy chain	3799	reviewed	Cellular structure
P35030	BXGT009784	Trypsin-3	5646	reviewed	Enzyme
P35558	BXGT009847	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	5105	reviewed	Kinase
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P42858	BXGT010341	Huntingtin	3064	reviewed
P45381	BXGT010460	Aspartoacylase	443	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P49448	BXGT010709	Glutamate dehydrogenase 2, mitochondrial	2747	reviewed	Enzyme
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49821	BXGT010748	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	4723	reviewed
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54136	BXGT011033	Arginine--tRNA ligase, cytoplasmic	5917	reviewed
P54802	BXGT011081	Alpha-N-acetylglucosaminidase	4669	reviewed
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q14117	BXGT013443	Dihydropyrimidinase	1807	reviewed	Enzyme
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q86Y39	BXGT017632	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	126328	reviewed
Q8TBE9	BXGT018790	N-acylneuraminate-9-phosphatase	140838	reviewed
Q96I59	BXGT019675	Probable asparagine--tRNA ligase, mitochondrial	79731	reviewed	Enzyme
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q9BY32	BXGT020179	Inosine triphosphate pyrophosphatase	3704	reviewed	Enzyme
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9H3S7	BXGT020467	Tyrosine-protein phosphatase non-receptor type 23	25930	reviewed
Q9HCB6	BXGT020529	Spondin-1	10418	reviewed	Extracellular structure
Q9UJW3	BXGT021732	DNA (cytosine-5)-methyltransferase 3-like	29947	reviewed
Q9ULC6	BXGT021759	Protein-arginine deiminase type-1	29943	reviewed
Q9Y3Z3	BXGT022268	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	25939	reviewed
P20138	BXGT023857	Myeloid cell surface antigen CD33	945	reviewed	Receptor
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}