Showing entry for Medullary carcinoma of thyroid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004937
Disease NameMedullary carcinoma of thyroid
Disease CUI IdC0238462
MeSH Codes C04   C19  
Disease Class NameNeoplasms; Endocrine System Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0000818   HP:0002664  
Human Phenotype Ontology TermAbnormality of the endocrine system; Neoplasm
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00255 BXGT003903 Menin 4221 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14763 BXGT004093 Tumor necrosis factor receptor superfamily member 10B 8795 reviewed
O43324 BXGT004588 Eukaryotic translation elongation factor 1 epsilon-1 9521 reviewed
O60609 BXGT004888 GDNF family receptor alpha-3 2676 reviewed
P00491 BXGT005555 Purine nucleoside phosphorylase 4860 reviewed Enzyme
P00505 BXGT005560 Aspartate aminotransferase, mitochondrial 2806 reviewed
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01275 BXGT005747 Glucagon 2641 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04083 BXGT006147 Annexin A1 301 reviewed
P04155 BXGT006155 Trefoil factor 1 7031 reviewed Signaling
P04183 BXGT006166 Thymidine kinase, cytosolic 7083 reviewed Kinase
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P05177 BXGT006336 Cytochrome P450 1A2 1544 reviewed Enzyme
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P06731 BXGT006488 Carcinoembryonic antigen-related cell adhesion molecule 5 1048 reviewed
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P09172 BXGT006865 Dopamine beta-hydroxylase 1621 reviewed
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10586 BXGT007581 Receptor-type tyrosine-protein phosphatase F 5792 reviewed Enzyme
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P10745 BXGT007608 Retinol-binding protein 3 5949 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12724 BXGT007837 Eosinophil cationic protein 6037 reviewed
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P13489 BXGT007913 Ribonuclease inhibitor 6050 reviewed Transcription factor
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 3248 reviewed
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 873 reviewed
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P16473 BXGT008234 Thyrotropin receptor 7253 reviewed G-protein coupled receptor
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P19971 BXGT008537 Thymidine phosphorylase 1890 reviewed Enzyme
P20132 BXGT008546 L-serine dehydratase/L-threonine deaminase 10993 reviewed Enzyme
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22736 BXGT008800 Nuclear receptor subfamily 4 group A member 1 3164 reviewed Nuclear receptor
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23528 BXGT008879 Cofilin-1 1072 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P27707 BXGT009201 Deoxycytidine kinase 1633 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28908 BXGT009302 Tumor necrosis factor receptor superfamily member 8 943 reviewed
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P30872 BXGT009474 Somatostatin receptor type 1 6751 reviewed G-protein coupled receptor
P30874 BXGT009475 Somatostatin receptor type 2 6752 reviewed G-protein coupled receptor
P30988 BXGT009491 Calcitonin receptor 799 reviewed G-protein coupled receptor
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P32239 BXGT009612 Gastrin/cholecystokinin type B receptor 887 reviewed G-protein coupled receptor
P33176 BXGT009699 Kinesin-1 heavy chain 3799 reviewed Cellular structure
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35346 BXGT009813 Somatostatin receptor type 5 6755 reviewed G-protein coupled receptor
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 2324 reviewed Kinase
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43220 BXGT010367 Glucagon-like peptide 1 receptor 2740 reviewed G-protein coupled receptor
P43235 BXGT010368 Cathepsin K 1513 reviewed Enzyme
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50750 BXGT010818 Cyclin-dependent kinase 9 1025 reviewed Kinase
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 6197 reviewed Kinase
P51884 BXGT010903 Lumican 4060 reviewed
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53985 BXGT011022 Monocarboxylate transporter 1 6566 reviewed Transporter
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61088 BXGT011358 Ubiquitin-conjugating enzyme E2 N 7334 reviewed
P62993 BXGT011480 Growth factor receptor-bound protein 2 2885 reviewed
P63279 BXGT011514 SUMO-conjugating enzyme UBC9 7329 reviewed
P78358 BXGT011838 Cancer/testis antigen 1 246100 reviewed
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q00796 BXGT012549 Sorbitol dehydrogenase 6652 reviewed Enzyme
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q04609 BXGT012768 Glutamate carboxypeptidase 2 2346 reviewed Enzyme
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q06710 BXGT012887 Paired box protein Pax-8 7849 reviewed
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q12866 BXGT013273 Tyrosine-protein kinase Mer 10461 reviewed Kinase
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q14002 BXGT013433 Carcinoembryonic antigen-related cell adhesion molecule 7 1087 reviewed
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14469 BXGT013473 Transcription factor HES-1 3280 reviewed Transcription factor
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 8851 reviewed Enzyme modulator
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q8IVS2 BXGT018349 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial 27349 reviewed
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q8WXD0 BXGT019009 Relaxin receptor 2 122042 reviewed G-protein coupled receptor
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q96JA1 BXGT019681 Leucine-rich repeats and immunoglobulin-like domains protein 1 26018 reviewed Receptor
Q99623 BXGT019941 Prohibitin-2 11331 reviewed
Q99653 BXGT019945 Calcineurin B homologous protein 1 11261 reviewed
Q9H492 BXGT020472 Microtubule-associated proteins 1A/1B light chain 3A 84557 reviewed Cellular structure
Q9H7B4 BXGT020490 Histone-lysine N-methyltransferase SMYD3 64754 reviewed Epigenetic regulator
Q9H9B1 BXGT020501 Histone-lysine N-methyltransferase EHMT1 79813 reviewed Epigenetic regulator
Q9HBX9 BXGT020523 Relaxin receptor 1 59350 reviewed G-protein coupled receptor
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9ULW0 BXGT021766 Targeting protein for Xklp2 22974 reviewed Cellular structure
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UN36 BXGT021780 Protein NDRG2 57447 reviewed Enzyme
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q92911 BXGT022650 Sodium/iodide cotransporter 6528 reviewed Transporter
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
P17535 BXGT023437 Transcription factor jun-D 3727 reviewed Transcription factor
P53539 BXGT023438 Protein fosB 2354 reviewed Transcription factor
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
P40198 BXGT023750 Carcinoembryonic antigen-related cell adhesion molecule 3 1084 reviewed
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
Q9P121 BXGT025711 Neurotrimin 50863 reviewed
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease