Showing entry for N-acetylgalactosamine-6-sulfatase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009749
Protein NameN-acetylgalactosamine-6-sulfatase
Uniport IdP34059
GeneGALNS
Gene Id2588
DomainSulfatase
Pfam PF00884  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00531 Glycosaminoglycan degradation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042340 keratan sulfate catabolic process
Biological Process GO:0043312 neutrophil degranulation
molecular function GO:0004065 arylsulfatase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0003943 N-acetylgalactosamine-4-sulfatase activity
molecular function GO:0043890 N-acetylgalactosamine-6-sulfatase activity
molecular function GO:0008484 sulfuric ester hydrolase activity
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0043202 lysosomal lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-1638074 Keratan sulfate/keratin metabolism
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2022857 Keratan sulfate degradation
R-HSA-2206281 Mucopolysaccharidoses
R-HSA-2206290 MPS IV - Morquio syndrome A
R-HSA-5663084 Diseases of carbohydrate metabolism
R-HSA-5668914 Diseases of metabolism
R-HSA-6798695 Neutrophil degranulation
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0001344 BXGD000043 Acute pharyngitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003175 BXGD000187 Anthrax disease Infections
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005890 BXGD000345 Body Height
C0005944 BXGD000355 Metabolic Bone Disorder Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0016397 BXGD001056 Focal Infection Infections
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019202 BXGD001302 Hepatolenticular Degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0021099 BXGD001479 Impetigo Infections; Skin and Connective Tissue Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0024441 BXGD001775 Macular Holes Eye Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026703 BXGD001919 Mucopolysaccharidoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026707 BXGD001922 Mucopolysaccharidosis IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031350 BXGD002300 Pharyngitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0034212 BXGD002473 Pyoderma Skin and Connective Tissue Diseases
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0036285 BXGD002592 Scarlet Fever Infections
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036689 BXGD002631 Streptococcal sore throat Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037278 BXGD002678 Skin Diseases, Infectious Infections; Skin and Connective Tissue Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0038395 BXGD002753 Streptococcal Infections Infections
C0038826 BXGD002779 Superinfection Infections
C0040425 BXGD002863 Tonsillitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042998 BXGD003021 Vulvovaginitis Female Urogenital Diseases and Pregnancy Complications
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0086651 BXGD003302 Mucopolysaccharidosis, MPS-IV-A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0086652 BXGD003303 Mucopolysaccharidosis type IVB Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0149645 BXGD003339 Cervical myelopathy Nervous System Diseases
C0149778 BXGD003362 Soft Tissue Infection Infections
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0156221 BXGD003842 Acute glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0231678 BXGD004506 Ulnar deviation of the wrist
C0238124 BXGD004883 Necrotizing fasciitis Musculoskeletal Diseases
C0239137 BXGD004965 Coxa valga Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0241654 BXGD005104 Abnormal heart valve morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242429 BXGD005166 Sore Throat Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0272386 BXGD006361 Hypertrophy of tonsils Pathological Conditions, Signs and Symptoms
C0276447 BXGD006425 Rhinovirus infection Infections
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0343532 BXGD007633 Streptococcal toxic shock syndrome Pathological Conditions, Signs and Symptoms; Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0432072 BXGD008718 Dysmorphic features
C0458385 BXGD008907 Site-specific infective disorders of skin Infections; Skin and Connective Tissue Diseases
C0473315 BXGD008938 Lactational amenorrhea
C0549523 BXGD009386 Oropharynx (excludes nasopharynx)
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0581381 BXGD009567 Recurrent upper respiratory tract infection Infections; Respiratory Tract Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C1283601 BXGD012164 Deficiency of sulfatase
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1510420 BXGD013158 Cavitation
C1512127 BXGD013185 HER2 gene amplification
C1844704 BXGD014665 Platyspondyly
C1844813 BXGD014679 Widely spaced teeth
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1846433 BXGD014813 Prominent sternum
C1846435 BXGD014815 Disproportionate short-trunk short stature
C1846439 BXGD014817 Hypoplasia of the odontoid process Musculoskeletal Diseases
C1846798 BXGD014839 Cervical subluxation
C1849039 BXGD014999 Metaphyseal widening
C1854780 BXGD015431 Flaring of rib cage
C1854783 BXGD015432 Grayish enamel
C1854785 BXGD015433 Constricted iliac wings
C1854786 BXGD015434 Epiphyseal deformities of tubular bones
C1854787 BXGD015435 Pointed proximal second through fifth metacarpals
C1855665 BXGD015524 Ovoid vertebral bodies
C2062441 BXGD016897 Influenza A
C2718068 BXGD017524 beta-Galactosidase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2732890 BXGD017559 Necrotizing soft tissue infection Infections
C2751898 BXGD017749 Ventricular Fibrillation, Paroxysmal Familial, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2827407 BXGD017795 Infectious Otitis Media Otorhinolaryngologic Diseases
C3179194 BXGD018548 GALNS Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C3277226 BXGD018711 Restrictive ventilatory defect
C3665382 BXGD019283 2,8-Dihydroxyadenine Urolithiasis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3715147 BXGD019446 Necrotising myositis Musculoskeletal Diseases; Nervous System Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4023059 BXGD021088 Chondroitin sulfate excretion in urine
C4023060 BXGD021089 Keratan sulfate excretion in urine
C4048329 BXGD021904 Immunosuppression
C4268744 BXGD022328 Atypical femoral fracture
C4280737 BXGD022395 Large elbow
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein