adisease

Showing entry for Acne

General Disease Information
BXGD Id	BXGD009912
Disease Name	Acne
Disease CUI Id	C0702166
MeSH Codes	C17
Disease Class Name	Skin and Connective Tissue Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001574 HP:0002715
Human Phenotype Ontology Term	Abnormality of the integument; Abnormality of the immune system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14770	BXGT004095	Homeobox protein Meis2	4212	reviewed	Enzyme
O15553	BXGT004181	Pyrin	4210	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O95255	BXGT005363	Multidrug resistance-associated protein 6	368	reviewed	Transporter
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P02656	BXGT005913	Apolipoprotein C-III	345	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05120	BXGT006319	Plasminogen activator inhibitor 2	5055	reviewed	Enzyme modulator
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P08133	BXGT006727	Annexin A6	309	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11912	BXGT007758	B-cell antigen receptor complex-associated protein alpha chain	973	reviewed	Receptor
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P14060	BXGT007978	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	3283	reviewed	Enzyme
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P16435	BXGT008226	NADPH--cytochrome P450 reductase	5447	reviewed
P17612	BXGT008322	cAMP-dependent protein kinase catalytic subunit alpha	5566	reviewed	Kinase
P20702	BXGT008592	Integrin alpha-X	3687	reviewed
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22749	BXGT008803	Granulysin	10578	reviewed
P23246	BXGT008840	Splicing factor, proline- and glutamine-rich	6421	reviewed	Nucleic acid binding
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P34059	BXGT009749	N-acetylgalactosamine-6-sulfatase	2588	reviewed	Enzyme
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36956	BXGT009947	Sterol regulatory element-binding protein 1	6720	reviewed
P37058	BXGT009956	Testosterone 17-beta-dehydrogenase 3	3293	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P47929	BXGT010598	Galectin-7	653499	reviewed	Signaling
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50225	BXGT010781	Sulfotransferase 1A1	6817	reviewed
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P55786	BXGT011125	Puromycin-sensitive aminopeptidase	9520	reviewed	Enzyme
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P61626	BXGT011382	Lysozyme C	4069	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P81605	BXGT011954	Dermcidin	117159	reviewed
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q86SG5	BXGT017599	Protein S100-A7A	338324	reviewed
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92959	BXGT019400	Solute carrier organic anion transporter family member 2A1	6578	reviewed	Transporter
Q96BI3	BXGT019623	Gamma-secretase subunit APH-1A	51107	reviewed	Enzyme modulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NZ08	BXGT021266	Endoplasmic reticulum aminopeptidase 1	51752	reviewed	Enzyme
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9Y239	BXGT022213	Nucleotide-binding oligomerization domain-containing protein 1	10392	reviewed	Enzyme
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}