Showing entry for Neurotrophin-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009752
Protein NameNeurotrophin-4
Uniport IdP34130
GeneNTF4
Gene Id4909
DomainNGF
Pfam PF00243  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0008544 epidermis development
Biological Process GO:0007402 ganglion mother cell fate determination
Biological Process GO:0060384 innervation
Biological Process GO:0007616 long-term memory
Biological Process GO:0042490 mechanoreceptor differentiation
Biological Process GO:0007613 memory
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0021675 nerve development
Biological Process GO:0038180 nerve growth factor signaling pathway
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0048011 neurotrophin TRK receptor signaling pathway
Biological Process GO:0007422 peripheral nervous system development
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0045664 regulation of neuron differentiation
Biological Process GO:0008052 sensory organ boundary specification
Biological Process GO:0061193 taste bud development
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0008083 growth factor activity
molecular function GO:0005163 nerve growth factor receptor binding
cellular component GO:0030424 axon
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0030425 dendrite
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008354 BXGD000533 Cholera Infections
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017605 BXGD001126 Angle Closure Glaucoma Eye Diseases
C0017606 BXGD001127 Primary angle-closure glaucoma Eye Diseases
C0017612 BXGD001129 Glaucoma, Open-Angle Eye Diseases
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0025202 BXGD001832 melanoma Neoplasms
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0162666 BXGD003967 Mitochondrial Encephalomyopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C2751294 BXGD017698 GLAUCOMA 1, OPEN ANGLE, O Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4539944 BXGD023230 SCHIZOPHRENIA 19
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein