Showing entry for Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009879
Protein NameRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Uniport IdP35913
GenePDE6B
Gene Id5158
DomainGAF; PDEase_I
Pfam PF01590   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.7 Sensory system hsa04744 Phototransduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043153 entrainment of circadian clock by photoperiod
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007603 phototransduction, visible light
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0022400 regulation of rhodopsin mediated signaling pathway
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0016056 rhodopsin mediated signaling pathway
Biological Process GO:0007601 visual perception
Biological Process GO:0007223 Wnt signaling pathway, calcium modulating pathway
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0097381 photoreceptor disc membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-4086398 Ca2+ pathway
R-HSA-4086398 Ca2+ pathway
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002136 BXGD000103 Allogenic disease
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154860 BXGD003752 Hereditary retinal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0220701 BXGD004325 RETINITIS PIGMENTOSA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0271093 BXGD006162 Stargardt's disease
C0271183 BXGD006169 Severe myopia Eye Diseases
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339526 BXGD007259 Autosomal recessive retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0521691 BXGD009163 Generalized progressive retinal atrophy
C0752166 BXGD010684 Bardet-Biedl Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1840077 BXGD014434 Anteverted nostril
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849367 BXGD015046 Nasal bridge wide
C1850362 BXGD015134 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1864877 BXGD016267 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1876182 BXGD016563 NIGHT BLINDNESS, CONGENITAL STATIONARY, AUTOSOMAL DOMINANT 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C3151107 BXGD018396 RETINITIS PIGMENTOSA 40 (disorder)
C3151111 BXGD018397 Abnormal light- and dark-adapted electroretinogram
C3161220 BXGD018509 Tuberculin (skin test) positive
C3495587 BXGD018996 Night Blindness, Congenital Stationary, Type 1A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3501847 BXGD019030 Night blindness, congenital stationary, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3551052 BXGD019144 Night blindness, stationary
C3711543 BXGD019396 X-Linked Csnb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024756 BXGD021405 Abnormality of macular pigmentation
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4041558 BXGD021877 Cone-rod synaptic disorder, congenital nonprogressive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein