Showing entry for G protein-coupled receptor kinase 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010372
Protein NameG protein-coupled receptor kinase 6
Uniport IdP43250
GeneGRK6
Gene Id2870
DomainPkinase; RGS
Pfam PF00069   PF00615  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0008277 regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0047696 beta-adrenergic receptor kinase activity
molecular function GO:0004703 G protein-coupled receptor kinase activity
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002994 BXGD000169 Angioedema Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009326 BXGD000598 Collagen Diseases Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013386 BXGD000827 Dyskinesia, Drug-Induced Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C0015526 BXGD001001 Factor XII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0019243 BXGD001308 Angioedemas, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030605 BXGD002248 Activated Partial Thromboplastin Time measurement
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153398 BXGD003631 Hypopharyngeal Cancer Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0201874 BXGD004054 Amino acids measurement
C0202202 BXGD004082 Protein measurement
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0280321 BXGD006739 Squamous cell carcinoma of the hypopharynx
C0311468 BXGD006885 Increased bilirubin level (finding) Pathological Conditions, Signs and Symptoms
C0523465 BXGD009209 Serum albumin measurement
C0523677 BXGD009215 Glycine measurement
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0876973 BXGD011322 Infectious Lung Disorder Infections; Respiratory Tract Diseases
C0883409 BXGD011395 Cardiac troponin I measurement
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1368404 BXGD012899 Hypopharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1629609 BXGD013479 Age at menopause
C1857728 BXGD015744 Hereditary Angioedema Type III Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C2239219 BXGD016966 von Willebrand's factor (lab test)
C2697764 BXGD017434 Interleukin 16 Measurement
C2985280 BXGD018223 Blood Protein Measurement
C3165106 BXGD018532 Infiltrating duct carcinoma of female breast Neoplasms; Skin and Connective Tissue Diseases
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C4017222 BXGD020424 FACTOR XII (LOCARNO) PHENOTYPE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001778 Scutellarein 286.24
BXGC0002588 Magnesium 24.31
BXGC0004275 Acetaldehyde 44.05
BXGC0005066 2R,3R-Butanediol 90.12
BXGC0005793 Baicalein 270.24
BXGC0009752 Methylhalfordinol 252.27
BXGC0012352 Chelerythrine 348.12
BXGC0024261 Adenosine Phosphate 347.06
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein