Showing entry for Sodium- and chloride-dependent glycine transporter 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010619
Protein NameSodium- and chloride-dependent glycine transporter 1
Uniport IdP48067
GeneSLC6A9
Gene Id6536
DomainSNF
Pfam PF00209  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1903804 glycine import across plasma membrane
Biological Process GO:0061537 glycine secretion, neurotransmission
Biological Process GO:0015816 glycine transport
Biological Process GO:1904782 negative regulation of NMDA glutamate receptor activity
Biological Process GO:0001504 neurotransmitter uptake
Biological Process GO:0070455 positive regulation of heme biosynthetic process
Biological Process GO:0046985 positive regulation of hemoglobin biosynthetic process
Biological Process GO:1904440 positive regulation of iron ion import across plasma membrane
Biological Process GO:1904256 positive regulation of iron ion transmembrane transporter activity
Biological Process GO:0150104 transport across blood-brain barrier
molecular function GO:0015375 glycine:sodium symporter activity
molecular function GO:0015187 glycine transmembrane transporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0009925 basal plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0031045 dense core granule
cellular component GO:0005768 endosome
cellular component GO:0098686 hippocampal mossy fiber to CA3 synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0098688 parallel fiber to Purkinje cell synapse
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0009024 BXGD000578 Clonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015930 BXGD001025 Fetal Distress Pathological Conditions, Signs and Symptoms
C0019553 BXGD001333 Hip Contracture Musculoskeletal Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0152235 BXGD003567 Congenital genu recurvatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0158486 BXGD003888 Acquired genu recurvatum Musculoskeletal Diseases
C0221358 BXGD004450 Long narrow head
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0236733 BXGD004822 Amphetamine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236804 BXGD004835 Amphetamine Addiction Chemically-Induced Disorders; Mental Disorders
C0236807 BXGD004836 Amphetamine Abuse Chemically-Induced Disorders; Mental Disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239234 BXGD004974 Low set ears
C0239815 BXGD004996 Hand clenching
C0265535 BXGD005544 Trigonocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0332615 BXGD006898 Myopathic facies
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0409338 BXGD008381 Flexion contracture - elbow
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0525041 BXGD009254 Neurobehavioral Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0546964 BXGD009348 Genu recurvatum
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0751748 BXGD010573 Nonketotic Hyperglycinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0871189 BXGD011312 Psychotic symptom
C0920299 BXGD011465 Overriding toe Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1533217 BXGD013313 Methamphetamine dependence Chemically-Induced Disorders; Mental Disorders
C1740801 BXGD013744 Exaggerated startle response
C1836542 BXGD014129 Depressed nasal bridge
C1840077 BXGD014434 Anteverted nostril
C1853738 BXGD015357 Long eyelashes
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3160814 BXGD018477 Cannabis use
C3278923 BXGD018748 Dilated ventricles (finding)
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C4310943 BXGD022687 GLYCINE ENCEPHALOPATHY WITH NORMAL SERUM GLYCINE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0002830 Sarkosin 89.09
BXGC0026092 Hinokinin 354.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein