Showing entry for T-complex protein 1 subunit epsilon


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010650
Protein NameT-complex protein 1 subunit epsilon
Uniport IdP48643
GeneCCT5
Gene Id22948
DomainCpn60_TCP1
Pfam PF00118  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007339 binding of sperm to zona pellucida
Biological Process GO:1904851 positive regulation of establishment of protein localization to telomere
Biological Process GO:1904871 positive regulation of protein localization to Cajal body
Biological Process GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0006457 protein folding
Biological Process GO:0050821 protein stabilization
Biological Process GO:0009615 response to virus
Biological Process GO:1901998 toxin transport
molecular function GO:0005524 ATP binding
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0031681 G-protein beta-subunit binding
molecular function GO:0003730 mRNA 3'-UTR binding
molecular function GO:0048027 mRNA 5'-UTR binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0044297 cell body
cellular component GO:0005813 centrosome
cellular component GO:0005832 chaperonin-containing T-complex
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005874 microtubule
Reactome
Pathway Id Pathway Name
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-391251 Protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5617833 Cilium Assembly
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009024 BXGD000578 Clonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030486 BXGD002229 Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699739 BXGD009861 Sensory Neuropathy, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0853085 BXGD010963 Decreased LDL cholesterol concentration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1389102 BXGD012964 Atrophy of the spinal cord
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836527 BXGD014127 Distal sensory impairment of all modalities
C1837522 BXGD014244 Impaired pain sensation
C1842587 BXGD014526 Sensory axonal neuropathy
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848736 BXGD014970 Distal amyotrophy
C1850395 BXGD015139 Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1855483 BXGD015501 Progressive spastic paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858729 BXGD015825 Decreased motor nerve conduction velocity
C3178789 BXGD018537 Widespread Chronic Pain Pathological Conditions, Signs and Symptoms
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4025722 BXGD021756 Abnormality of the spinal cord
C4049342 BXGD021926 Foot osteomyelitis Infections; Musculoskeletal Diseases
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4732740 BXGD023896 Acral ulceration
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein