Showing entry for Ubiquitin-conjugating enzyme E2 B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011504
Protein NameUbiquitin-conjugating enzyme E2 B
Uniport IdP63146
GeneUBE2B
Gene Id7320
DomainUQ_con
Pfam PF00179  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0051026 chiasma assembly
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0006281 DNA repair
Biological Process GO:0070829 heterochromatin maintenance
Biological Process GO:0033522 histone H2A ubiquitination
Biological Process GO:0070076 histone lysine demethylation
Biological Process GO:0016574 histone ubiquitination
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0045141 meiotic telomere clustering
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0033128 negative regulation of histone phosphorylation
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0010845 positive regulation of reciprocal meiotic recombination
Biological Process GO:0006301 postreplication repair
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0070979 protein K11-linked ubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0006513 protein monoubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0050821 protein stabilization
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0042493 response to drug
Biological Process GO:0009411 response to UV
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0007288 sperm axoneme assembly
Biological Process GO:0070193 synaptonemal complex organization
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0061631 ubiquitin conjugating enzyme activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0000785 chromatin
cellular component GO:0005737 cytoplasm
cellular component GO:0033503 HULC complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0005657 replication fork
cellular component GO:0001741 XY body
Reactome
Pathway Id Pathway Name
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-8852135 Protein ubiquitination
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008055 BXGD000514 Chikungunya Fever Infections
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014522 BXGD000922 Epidermodysplasia Verruciformis Infections; Skin and Connective Tissue Diseases
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0030354 BXGD002214 Papilloma Neoplasms
C0034494 BXGD002481 Rabies (disorder) Infections
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036916 BXGD002643 Sexually Transmitted Diseases Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0042749 BXGD002998 Viremia Pathological Conditions, Signs and Symptoms; Infections
C0042769 BXGD002999 Virus Diseases Infections
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152517 BXGD003604 Viral gastroenteritis Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Infections
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0242510 BXGD005173 Drug usage Chemically-Induced Disorders; Mental Disorders
C0275524 BXGD006376 Coinfection Infections
C0275544 BXGD006377 Congenital infectious disease Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0349458 BXGD007906 Cervical intraepithelial neoplasia grade 1 Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0814152 BXGD010858 Viral hepatitis, type G Infections
C0920350 BXGD011466 Autoimmune thyroiditis Immune System Diseases; Endocrine System Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3539781 BXGD019086 Progressive cGVHD
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein