Showing entry for Ankyrin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012592
Protein NameAnkyrin-2
Uniport IdQ01484
GeneANK2
Gene Id287
DomainAnk; Death; UPA_2; ZU5
Pfam PF00023   PF12796   PF00531   PF17809   PF00791  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086014 atrial cardiac muscle cell action potential
Biological Process GO:0086066 atrial cardiac muscle cell to AV node cell communication
Biological Process GO:0003283 atrial septum development
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0006897 endocytosis
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0086046 membrane depolarization during SA node cell action potential
Biological Process GO:0030913 paranodal junction assembly
Biological Process GO:1901021 positive regulation of calcium ion transmembrane transporter activity
Biological Process GO:0051928 positive regulation of calcium ion transport
Biological Process GO:2001259 positive regulation of cation channel activity
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1901018 positive regulation of potassium ion transmembrane transporter activity
Biological Process GO:0043268 positive regulation of potassium ion transport
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:0070972 protein localization to endoplasmic reticulum
Biological Process GO:0036309 protein localization to M-band
Biological Process GO:0033365 protein localization to organelle
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0036371 protein localization to T-tubule
Biological Process GO:0050821 protein stabilization
Biological Process GO:0015031 protein transport
Biological Process GO:0098910 regulation of atrial cardiac muscle cell action potential
Biological Process GO:1901019 regulation of calcium ion transmembrane transporter activity
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0086004 regulation of cardiac muscle cell contraction
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0051279 regulation of release of sequestered calcium ion into cytosol
Biological Process GO:0098907 regulation of SA node cell action potential
Biological Process GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
Biological Process GO:0051597 response to methylmercury
Biological Process GO:0086015 SA node cell action potential
Biological Process GO:0086070 SA node cell to atrial cardiac muscle cell communication
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0033292 T-tubule organization
Biological Process GO:0086005 ventricular cardiac muscle cell action potential
molecular function GO:0051117 ATPase binding
molecular function GO:0008093 cytoskeletal anchor activity
molecular function GO:0019899 enzyme binding
molecular function GO:0044325 ion channel binding
molecular function GO:0140031 phosphorylation-dependent protein binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0030507 spectrin binding
molecular function GO:0005200 structural constituent of cytoskeleton
cellular component GO:0031672 A band
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0043034 costamere
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0014704 intercalated disc
cellular component GO:0005764 lysosome
cellular component GO:0031430 M band
cellular component GO:0045121 membrane raft
cellular component GO:0005739 mitochondrion
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0042383 sarcolemma
cellular component GO:0030315 T-tubule
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019099 BXGD001282 Hemorrhagic Fever, Crimean Infections
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085610 BXGD003202 Sinus bradycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151878 BXGD003495 Prolonged QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0340464 BXGD007332 Premature Cardiac Complex Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0748061 BXGD010189 psychiatric hospitalization
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0855329 BXGD011084 Electrocardiogram change
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1560249 BXGD013361 Adverse Event Associated with Cardiac Arrhythmia
C1560305 BXGD013362 Prolonged QTc interval
C1563715 BXGD013389 Andersen Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1833154 BXGD013899 Long Qt Syndrome 4 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1839341 BXGD014370 Abnormal T-wave
C1853833 BXGD015363 Parkinson Disease 6, Autosomal Recessive Early-Onset Nervous System Diseases
C1858430 BXGD015792 Death in infancy
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1963175 BXGD016687 Sinus Bradycardia, CTCAE
C1963217 BXGD016689 Prolonged QTc Interval, CTCAE
C1970119 BXGD016809 CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2108107 BXGD016920 continuous electrocardiogram sinus bradycardia (finding)
C4025797 BXGD021795 Abnormality of prenatal development or birth
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4477077 BXGD022917 Abnormal cardiac exercise stress test
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein