Showing entry for Centromere-associated protein E


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012643
Protein NameCentromere-associated protein E
Uniport IdQ02224
GeneCENPE
Gene Id1062
DomainKinesin
Pfam PF00225  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0051315 attachment of mitotic spindle microtubules to kinetochore
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0051382 kinetochore assembly
Biological Process GO:0099607 lateral attachment of mitotic spindle microtubules to kinetochore
Biological Process GO:0051310 metaphase plate congression
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0099606 microtubule plus-end directed mitotic chromosome migration
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0007079 mitotic chromosome movement towards spindle pole
Biological Process GO:0007080 mitotic metaphase plate congression
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0030071 regulation of mitotic metaphase/anaphase transition
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
molecular function GO:0005524 ATP binding
molecular function GO:0043515 kinetochore binding
molecular function GO:0008017 microtubule binding
molecular function GO:0003777 microtubule motor activity
cellular component GO:0005694 chromosome
cellular component GO:0000775 chromosome, centromeric region
cellular component GO:0000779 condensed chromosome, centromeric region
cellular component GO:0000777 condensed chromosome kinetochore
cellular component GO:0005829 cytosol
cellular component GO:0000776 kinetochore
cellular component GO:0005828 kinetochore microtubule
cellular component GO:0016020 membrane
cellular component GO:0005874 microtubule
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0030496 midbody
cellular component GO:1990023 mitotic spindle midzone
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0051233 spindle midzone
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-168256 Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017601 BXGD001125 Glaucoma Eye Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039590 BXGD002822 Testicular Neoplasms Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0239479 BXGD004982 Round face
C0240538 BXGD005041 Convex nasal ridge
C0265202 BXGD005461 Seckel syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426415 BXGD008560 Large nose
C0431350 BXGD008668 Primary microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0431368 BXGD008673 Partial agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432246 BXGD008754 Microcephalic Osteodysplastic Primordial Dwarfism, Type II Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0521158 BXGD009130 Recurrent tumor
C0541764 BXGD009259 Delayed bone age
C0557874 BXGD009444 Global developmental delay
C0575802 BXGD009521 Small hand
C0576226 BXGD009527 Short foot
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1336708 BXGD012852 Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1837463 BXGD014235 Narrow face
C1840069 BXGD014433 Sandal gap
C1848673 BXGD014963 Hypoplastic feet
C1849364 BXGD015045 Absent earlobe
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1857042 BXGD015669 Sparse scalp hair
C1857656 BXGD015731 Prematurely aged appearance
C1857679 BXGD015735 Sloping forehead
C1865037 BXGD016289 Cone-shaped epiphysis
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2749675 BXGD017631 Cortical gyral simplification
C2919142 BXGD017867 Short Stature, CTCAE
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3552526 BXGD019156 Metaphyseal sclerosis
C3553764 BXGD019187 Joint hyperflexibility
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4012968 BXGD020124 Mild global developmental delay
C4015080 BXGD020182 MICROCEPHALY 13, PRIMARY, AUTOSOMAL RECESSIVE
C4021800 BXGD020790 Abnormality of dental enamel
C4024202 BXGD021303 Reduced number of teeth
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0002722 Nitrate 62
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein