Showing entry for Potassium voltage-gated channel subfamily C member 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013434
Protein NamePotassium voltage-gated channel subfamily C member 3
Uniport IdQ14003
GeneKCNC3
Gene Id3748
DomainBTB_2; Ion_trans; Potassium_chann
Pfam PF02214   PF00520   PF11404  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0034765 regulation of ion transmembrane transport
molecular function GO:0005251 delayed rectifier potassium channel activity
molecular function GO:0005249 voltage-gated potassium channel activity
cellular component GO:0030424 axon
cellular component GO:0005938 cell cortex
cellular component GO:0005856 cytoskeleton
cellular component GO:0032590 dendrite membrane
cellular component GO:0032591 dendritic spine membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0032809 neuronal cell body membrane
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0042734 presynaptic membrane
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040485 BXGD002871 Torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231690 BXGD004512 Titubation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233844 BXGD004620 Clumsiness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0349588 BXGD007933 Short stature
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0554970 BXGD009428 Pallor of optic disc
C0557874 BXGD009444 Global developmental delay
C0560346 BXGD009475 Difficulty running Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1504404 BXGD013141 Hippocampal sclerosis
C1611743 BXGD013456 Familial (FPAH)
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846176 BXGD014791 Hyperactive deep tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1853558 BXGD015344 Jerky ocular pursuit movements
C1853767 BXGD015361 Impaired distal vibration sensation
C1854301 BXGD015391 Motor delay Mental Disorders
C1854488 BXGD015407 Spinocerebellar ataxia 13 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1854489 BXGD015408 Limb dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2919142 BXGD017867 Short Stature, CTCAE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021761 BXGD020763 Morphological abnormality of the pyramidal tract
C4023701 BXGD021248 Impaired visuospatial constructive cognition
C4476705 BXGD022849 Upgaze palsy
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047867 Dalfampridine 94.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein