Showing entry for cGMP-inhibited 3',5'-cyclic phosphodiesterase A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013469
Protein NamecGMP-inhibited 3',5'-cyclic phosphodiesterase A
Uniport IdQ14432
GenePDE3A
Gene Id5139
DomainPDEase_I
Pfam PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0071321 cellular response to cGMP
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0001556 oocyte maturation
Biological Process GO:0060282 positive regulation of oocyte development
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:0040020 regulation of meiotic nuclear division
Biological Process GO:0042493 response to drug
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0085220 BXGD003142 Cerebral Amyloid Angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0087086 BXGD003320 Thrombus Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151489 BXGD003427 Arterial malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0202236 BXGD004086 Triglycerides measurement
C0220659 BXGD004314 Acrodysostosis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234119 BXGD004622 Neuromuscular inhibition
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0349588 BXGD007933 Short stature
C0392885 BXGD008071 High density lipoprotein measurement
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424678 BXGD008537 Lean body mass
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0429028 BXGD008646 QT interval feature (observable entity)
C0489786 BXGD009018 Height
C0598428 BXGD009665 genetic hypertension Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0871470 BXGD011316 Systolic Pressure
C0877165 BXGD011338 Short phalanx of finger
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1300206 BXGD012271 Blomstrand dysplasia
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1837084 BXGD014195 Short metacarpal
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1862170 BXGD016114 Brachydactyly with hypertension Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3665731 BXGD019300 Intracranial artery dissection
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0001502 Caffeine 194.19
BXGC0029783 Benzoylenurea 162.04
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein