Showing entry for Neutrophil cytosol factor 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013535
Protein NameNeutrophil cytosol factor 4
Uniport IdQ15080
GeneNCF4
Gene Id4689
DomainPB1; PX; SH3_1
Pfam PF00564   PF00787   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05140 Leishmaniasis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0006909 phagocytosis
Biological Process GO:0045730 respiratory burst
Biological Process GO:0006801 superoxide metabolic process
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0032266 phosphatidylinositol-3-phosphate binding
molecular function GO:0016176 superoxide-generating NADPH oxidase activator activity
molecular function GO:0016175 superoxide-generating NADPH oxidase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0010008 endosome membrane
cellular component GO:0016020 membrane
cellular component GO:0043020 NADPH oxidase complex
cellular component GO:0032010 phagolysosome
Reactome
Pathway Id Pathway Name
R-HSA-1222556 ROS and RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-2262752 Cellular responses to stress
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0018203 BXGD001184 Chronic granulomatous disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023885 BXGD001711 Liver Abscess Digestive System Diseases; Infections
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040588 BXGD002879 Tracheoesophageal Fistula Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Respiratory Tract Diseases
C0079745 BXGD003091 Lymphoma, Large-Cell, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0175702 BXGD004008 Williams Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0267380 BXGD005743 Crohn's disease of the ileum Digestive System Diseases
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0427515 BXGD008619 Neutrophil abnormality
C0520743 BXGD009107 Mediastinal lymphadenopathy Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0581354 BXGD009561 Recurrent sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0678202 BXGD009747 Regional enteritis Digestive System Diseases
C0949272 BXGD011573 IIeocolitis Digestive System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1396126 BXGD012992 Perioral eczema Skin and Connective Tissue Diseases
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1842774 BXGD014536 Hypermelanotic macule
C1844376 BXGD014627 Granulomatous Disease, Chronic, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1863999 BXGD016208 Peroxisome Biogenesis Disorder, Complementation Group D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1963165 BXGD016685 Malabsorption, CTCAE
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C3151409 BXGD018425 GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-POSITIVE, TYPE III
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C4020969 BXGD020517 Inflammatory abnormality of the eye
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein