Showing entry for MAP kinase-activated protein kinase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013647
Protein NameMAP kinase-activated protein kinase 3
Uniport IdQ16644
GeneMAPKAPK3
Gene Id7867
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04370 VEGF signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0044351 macropinocytosis
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0034097 response to cytokine
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0007165 signal transduction
Biological Process GO:0002224 toll-like receptor signaling pathway
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0009931 calcium-dependent protein serine/threonine kinase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0004708 MAP kinase kinase activity
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-167044 Signalling to RAS
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-171007 p38MAPK events
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187687 Signalling to ERKs
R-HSA-194138 Signaling by VEGF
R-HSA-2262752 Cellular responses to stress
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-450302 activated TAK1 mediates p38 MAPK activation
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0221232 BXGD004413 Welts Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0423421 BXGD008484 Atrophic macular change
C0429908 BXGD008655 Susceptibility to tuberculosis
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837029 BXGD014188 Macular Dystrophy, Butterfly-Shaped Pigmentary, 2 Eye Diseases
C1868569 BXGD016507 Patterned dystrophy of retinal pigment epithelium Eye Diseases
C1970028 BXGD016803 MALARIA, SUSCEPTIBILITY TO (finding)
C3280647 BXGD018851 BACTEREMIA, SUSCEPTIBILITY TO, 2
C4310713 BXGD022635 MACULAR DYSTROPHY, PATTERNED, 3
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0007014 Harman 182.22
BXGC0012352 Chelerythrine 348.12
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein