Showing entry for Endoplasmic reticulum aminopeptidase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016440
Protein NameEndoplasmic reticulum aminopeptidase 2
Uniport IdQ6P179
GeneERAP2
Gene Id64167
DomainERAP1_C; Peptidase_M1; Peptidase_M1_N
Pfam PF11838   PF01433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
Biological Process GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
Biological Process GO:0043171 peptide catabolic process
Biological Process GO:0006508 proteolysis
Biological Process GO:0008217 regulation of blood pressure
molecular function GO:0004177 aminopeptidase activity
molecular function GO:0070006 metalloaminopeptidase activity
molecular function GO:0008237 metallopeptidase activity
molecular function GO:0042277 peptide binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009447 BXGD000613 Common Variable Immunodeficiency Immune System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0031036 BXGD002273 Polyarteritis Nodosa Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0267380 BXGD005743 Crohn's disease of the ileum Digestive System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0678202 BXGD009747 Regional enteritis Digestive System Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0701807 BXGD009901 Acute anterior uveitis Eye Diseases
C0920350 BXGD011466 Autoimmune thyroiditis Immune System Diseases; Endocrine System Diseases
C0949272 BXGD011573 IIeocolitis Digestive System Diseases
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1709457 BXGD013625 Papillary Thyroid Microcarcinoma Neoplasms; Endocrine System Diseases
C1853959 BXGD015372 Birdshot chorioretinopathy
C2363741 BXGD017100 HIV-1 infection
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2985280 BXGD018223 Blood Protein Measurement
C3150797 BXGD018337 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3887654 BXGD019912 POLYARTERITIS NODOSA, CHILDHOOD-ONSET Skin and Connective Tissue Diseases; Cardiovascular Diseases
C4014795 BXGD020166 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4310768 BXGD022658 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002052 Aesculetin 178.14
BXGC0006291 Scopoletin 192.17
BXGC0014116 Lysine 147.11
BXGC0018397 beta-1,4-mannan 180.06
BXGC0027558 oscillaginin A 614.31
BXGC0028036 Esculin hydrate 340.08
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein