Showing entry for Myosin-14


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017251
Protein NameMyosin-14
Uniport IdQ7Z406
GeneMYH14
Gene Id79784
DomainMyosin_head; Myosin_N; Myosin_tail_1
Pfam PF00063   PF02736   PF01576  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05132 Salmonella infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0070584 mitochondrion morphogenesis
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0071625 vocalization behavior
molecular function GO:0030898 actin-dependent ATPase activity
molecular function GO:0051015 actin filament binding
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0000146 microfilament motor activity
cellular component GO:0042641 actomyosin
cellular component GO:0005903 brush border
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0030426 growth cone
cellular component GO:0016020 membrane
cellular component GO:0016460 myosin II complex
cellular component GO:0097513 myosin II filament
cellular component GO:0001725 stress fiber
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-195258 RHO GTPase Effectors
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373755 Semaphorin interactions
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-422475 Axon guidance
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016169 BXGD001048 pathologic fistula Pathological Conditions, Signs and Symptoms
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026244 BXGD001893 Mitochondrial Swelling
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202455 BXGD004090 Platinum measurement
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0345218 BXGD007719 Low anorectal malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C0848765 BXGD010885 Hearing disability
C0854078 BXGD010996 Diabetic end stage renal disease
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1833503 BXGD013929 Deafness, Autosomal Dominant 4 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836609 BXGD014138 Progressive distal muscle weakness
C1842160 BXGD014501 MYOPATHY, MYOSIN STORAGE (disorder) Musculoskeletal Diseases; Nervous System Diseases
C1843156 BXGD014561 Progressive sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1843700 BXGD014604 Increased variability in muscle fiber diameter
C1848736 BXGD014970 Distal amyotrophy
C1857640 BXGD015726 Decreased nerve conduction velocity
C2936864 BXGD018149 Bardet-Biedl syndrome 4 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3280556 BXGD018844 PERIPHERAL NEUROPATHY, MYOPATHY, HOARSENESS, AND HEARING LOSS
C3495676 BXGD019000 Anorectal Malformations Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4021082 BXGD020543 Fatty replacement of skeletal muscle
C4021533 BXGD020656 Severe sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4023965 BXGD021281 Structural foot deformity Musculoskeletal Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein