adisease

Showing entry for Cleft upper lip

General Disease Information
BXGD Id	BXGD000574
Disease Name	Cleft upper lip
Disease CUI Id	C0008924
MeSH Codes	C16 C07
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
Semantic Type	Congenital Abnormality
Human Phenotype Ontology Id	HP:0000152
Human Phenotype Ontology Term	Abnormality of head or neck
Disease Ontology Id	DOID:7 DOID:225 DOID:0080015
Disease Ontology Class Name	disease of anatomical entity; syndrome; physical disorder
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14770	BXGT004095	Homeobox protein Meis2	4212	reviewed	Enzyme
O15530	BXGT004177	3-phosphoinositide-dependent protein kinase 1	5170	reviewed	Kinase
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O43597	BXGT004602	Protein sprouty homolog 2	10253	reviewed	Signaling
O75347	BXGT005113	Tubulin-specific chaperone A	6902	reviewed	Chaperone
O75369	BXGT005119	Filamin-B	2317	reviewed
O95257	BXGT005365	Growth arrest and DNA damage-inducible protein GADD45 gamma	10912	reviewed
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O96028	BXGT005417	Histone-lysine N-methyltransferase NSD2	7468	reviewed	Epigenetic regulator
P00488	BXGT005552	Coagulation factor XIII A chain	2162	reviewed	Enzyme
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P0CG47	BXGT007467	Polyubiquitin-B	7314	reviewed	Nucleic acid binding
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10827	BXGT007623	Thyroid hormone receptor alpha	7067	reviewed	Nuclear receptor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P12830	BXGT007852	Cadherin-1	999	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14923	BXGT008069	Junction plakoglobin	3728	reviewed
P20062	BXGT008543	Transcobalamin-2	6948	reviewed
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P27482	BXGT009185	Calmodulin-like protein 3	810	reviewed	Calcium-binding protein
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	2562	reviewed	Ion channel
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P41227	BXGT010238	N-alpha-acetyltransferase 10	8260	reviewed	Enzyme
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48740	BXGT010659	Mannan-binding lectin serine protease 1	5648	reviewed	Enzyme
P49761	BXGT010736	Dual specificity protein kinase CLK3	1198	reviewed	Kinase
P49914	BXGT010762	5-formyltetrahydrofolate cyclo-ligase	10588	reviewed	Enzyme
P51955	BXGT010908	Serine/threonine-protein kinase Nek2	4751	reviewed	Kinase
P54753	BXGT011073	Ephrin type-B receptor 3	2049	reviewed	Kinase
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P62508	BXGT011431	Estrogen-related receptor gamma	2104	reviewed	Nuclear receptor
P63165	BXGT011506	Small ubiquitin-related modifier 1	7341	reviewed
Q02127	BXGT012635	Dihydroorotate dehydrogenase (quinone), mitochondrial	1723	reviewed	Enzyme
Q05932	BXGT012845	Folylpolyglutamate synthase, mitochondrial	2356	reviewed	Enzyme
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q13188	BXGT013324	Serine/threonine-protein kinase 3	6788	reviewed	Kinase
Q13363	BXGT013344	C-terminal-binding protein 1	1487	reviewed	Transcription factor
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q15223	BXGT013551	Nectin-1	5818	reviewed
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q4KMG0	BXGT014850	Cell adhesion molecule-related/down-regulated by oncogenes	50937	reviewed
Q7Z3B3	BXGT017249	KAT8 regulatory NSL complex subunit 1	284058	reviewed
Q7Z406	BXGT017251	Myosin-14	79784	reviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8NCM8	BXGT018548	Cytoplasmic dynein 2 heavy chain 1	79659	reviewed	Enzyme
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q9BWP8	BXGT020153	Collectin-11	78989	reviewed	Surfactant
Q9H2M3	BXGT020456	S-methylmethionine--homocysteine S-methyltransferase BHMT2	23743	reviewed
Q9HBH9	BXGT020521	MAP kinase-interacting serine/threonine-protein kinase 2	2872	reviewed	Kinase
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UPP1	BXGT021800	Histone lysine demethylase PHF8	23133	reviewed
Q9UPZ9	BXGT021804	Serine/threonine-protein kinase ICK	22858	reviewed	Kinase
P56703	BXGT023722	Proto-oncogene Wnt-3	7473	reviewed	Signaling
Q99958	BXGT023732	Forkhead box protein C2	2303	reviewed	Transcription factor
Q9H9S5	BXGT024623	Fukutin-related protein	79147	reviewed
Q9H0W8	BXGT024746	Protein SMG9	56006	reviewed
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
Q9NRR4	BXGT025788	Ribonuclease 3	29102	reviewed	Enzyme
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}