Showing entry for Interferon lambda-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018331
Protein NameInterferon lambda-1
Uniport IdQ8IU54
GeneIFNL1
Gene Id282618
DomainIL28A
Pfam PF15177  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0051607 defense response to virus
Biological Process GO:0045087 innate immune response
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0032696 negative regulation of interleukin-13 production
Biological Process GO:0032714 negative regulation of interleukin-5 production
Biological Process GO:0043381 negative regulation of memory T cell differentiation
Biological Process GO:0045581 negative regulation of T cell differentiation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0002829 negative regulation of type 2 immune response
Biological Process GO:0050778 positive regulation of immune response
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0045345 positive regulation of MHC class I biosynthetic process
Biological Process GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0007259 receptor signaling pathway via JAK-STAT
molecular function GO:0005125 cytokine activity
molecular function GO:0032003 interleukin-28 receptor binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0032002 interleukin-28 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-449147 Signaling by Interleukins
R-HSA-449836 Other interleukin signaling
R-HSA-8854691 Interleukin-20 family signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001342 BXGD000042 Acute periodontitis Stomatognathic Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006271 BXGD000384 Bronchiolitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008055 BXGD000514 Chikungunya Fever Infections
C0011311 BXGD000714 Dengue Fever Infections
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031106 BXGD002283 Aggressive Periodontitis Stomatognathic Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038522 BXGD002767 Subacute Sclerosing Panencephalitis Infections; Nervous System Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085293 BXGD003154 Hepatitis E Digestive System Diseases; Infections
C0085409 BXGD003168 Polyendocrinopathies, Autoimmune Immune System Diseases; Endocrine System Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0276447 BXGD006425 Rhinovirus infection Infections
C0276623 BXGD006433 Chronic viral hepatitis Digestive System Diseases
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0392171 BXGD008033 Influenza-like symptoms
C0400914 BXGD008263 Acute hepatitis C Digestive System Diseases; Infections
C0409980 BXGD008403 Primary antiphospholipid syndrome Immune System Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0858004 BXGD011168 Influenza A virus infection Infections; Respiratory Tract Diseases
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1303258 BXGD012323 Acute ST segment elevation myocardial infarction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319860 BXGD012419 Sendai virus infection Infections
C1719495 BXGD013656 Aggressive periodontitis, generalized Stomatognathic Diseases
C1832588 BXGD013856 Chromosome 11p11.2 Deletion Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C1849193 BXGD015022 PEELING SKIN SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2711110 BXGD017477 Hepatitis B and hepatitis C Digestive System Diseases; Infections
C3714514 BXGD019409 Infection Infections
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4023560 BXGD021217 Generalized periodontitis Stomatognathic Diseases
C4524092 BXGD023092 Chronic rhinosinusitis with nasal polyps
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein