adisease

Showing entry for Allergic asthma

General Disease Information
BXGD Id	BXGD003830
Disease Name	Allergic asthma
Disease CUI Id	C0155877
MeSH Codes	C08 C20
Disease Class Name	Respiratory Tract Diseases; Immune System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O43353	BXGT004589	Receptor-interacting serine/threonine-protein kinase 2	8767	reviewed	Kinase
O43813	BXGT004628	Glutathione S-transferase LANCL1	10314	reviewed
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01031	BXGT005720	Complement C5	727	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01730	BXGT005781	T-cell surface glycoprotein CD4	920	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02763	BXGT005951	Alpha-1-acid glycoprotein 1	5004	reviewed
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	1129	reviewed	G-protein coupled receptor
P08700	BXGT006816	Interleukin-3	3562	reviewed
P08865	BXGT006832	40S ribosomal protein SA	3921	reviewed	Nucleic acid binding
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10153	BXGT007544	Non-secretory ribonuclease	6036	reviewed
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11678	BXGT007736	Eosinophil peroxidase	8288	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	3620	reviewed
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	2167	reviewed
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16066	BXGT008185	Atrial natriuretic peptide receptor 1	4881	reviewed	Kinase
P16144	BXGT008200	Integrin beta-4	3691	reviewed	Receptor
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21549	BXGT008661	Serine--pyruvate aminotransferase	189	reviewed	Enzyme
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21730	BXGT008687	C5a anaphylatoxin chemotactic receptor 1	728	reviewed	G-protein coupled receptor
P23469	BXGT008871	Receptor-type tyrosine-protein phosphatase epsilon	5791	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23946	BXGT008932	Chymase	1215	reviewed	Enzyme
P24071	BXGT008945	Immunoglobulin alpha Fc receptor	2204	reviewed	Receptor
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P25105	BXGT009021	Platelet-activating factor receptor	5724	reviewed	G-protein coupled receptor
P25705	BXGT009060	ATP synthase subunit alpha, mitochondrial	498	reviewed	Transporter
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P26951	BXGT009147	Interleukin-3 receptor subunit alpha	3563	reviewed	Signaling
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27815	BXGT009208	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	5141	reviewed
P28039	BXGT009224	Acyloxyacyl hydrolase	313	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29508	BXGT009358	Serpin B3	6317	reviewed	Enzyme modulator
P30101	BXGT009402	Protein disulfide-isomerase A3	2923	reviewed
P30411	BXGT009424	B2 bradykinin receptor	624	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P30989	BXGT009492	Neurotensin receptor type 1	4923	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32929	BXGT009682	Cystathionine gamma-lyase	1491	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35247	BXGT009804	Pulmonary surfactant-associated protein D	6441	reviewed	Surfactant
P35367	BXGT009821	Histamine H1 receptor	3269	reviewed	G-protein coupled receptor
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P38484	BXGT010042	Interferon gamma receptor 2	3460	reviewed	Receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P47712	BXGT010577	Cytosolic phospholipase A2	5321	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49023	BXGT010672	Paxillin	5829	reviewed	Cellular structure
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50135	BXGT010776	Histamine N-methyltransferase	3176	reviewed
P51665	BXGT010874	26S proteasome non-ATPase regulatory subunit 7	5713	reviewed	Enzyme
P51677	BXGT010876	C-C chemokine receptor type 3	1232	reviewed	G-protein coupled receptor
P51679	BXGT010877	C-C chemokine receptor type 4	1233	reviewed	G-protein coupled receptor
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51686	BXGT010881	C-C chemokine receptor type 9	10803	reviewed	G-protein coupled receptor
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P55774	BXGT011124	C-C motif chemokine 18	6362	reviewed	Signaling
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61586	BXGT011375	Transforming protein RhoA	387	reviewed	Enzyme modulator
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
P78504	BXGT011844	Protein jagged-1	182	reviewed
P78540	BXGT011848	Arginase-2, mitochondrial	384	reviewed	Enzyme
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q01344	BXGT012585	Interleukin-5 receptor subunit alpha	3568	reviewed	Signaling
Q03403	BXGT012712	Trefoil factor 2	7032	reviewed	Signaling
Q03518	BXGT012723	Antigen peptide transporter 1	6890	reviewed	Transporter
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q07011	BXGT012912	Tumor necrosis factor receptor superfamily member 9	3604	reviewed
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q08174	BXGT012963	Protocadherin-1	5097	reviewed
Q13118	BXGT013312	Krueppel-like factor 10	7071	reviewed	Nucleic acid binding
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13219	BXGT013327	Pappalysin-1	5069	reviewed
Q13231	BXGT013329	Chitotriosidase-1	1118	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14627	BXGT013492	Interleukin-13 receptor subunit alpha-2	3598	reviewed	Signaling
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15382	BXGT013563	GTP-binding protein Rheb	6009	reviewed	Enzyme modulator
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16873	BXGT013684	Leukotriene C4 synthase	4056	reviewed	Enzyme
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6W5P4	BXGT016588	Neuropeptide S receptor	387129	reviewed
Q8IU54	BXGT018331	Interferon lambda-1	282618	reviewed
Q8IUF8	BXGT018334	Ribosomal oxygenase 2	84864	reviewed
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8TAX9	BXGT018788	Gasdermin-B	55876	reviewed
Q8TDQ0	BXGT018810	Hepatitis A virus cellular receptor 2	84868	reviewed
Q92993	BXGT019403	Histone acetyltransferase KAT5	10524	reviewed
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96F46	BXGT019656	Interleukin-17 receptor A	23765	reviewed
Q96KS0	BXGT019688	Egl nine homolog 2	112398	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q99489	BXGT019924	D-aspartate oxidase	8528	reviewed
Q9BZ11	BXGT020193	Disintegrin and metalloproteinase domain-containing protein 33	80332	reviewed	Enzyme
Q9BZP6	BXGT020201	Acidic mammalian chitinase	27159	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9C098	BXGT020208	Serine/threonine-protein kinase DCLK3	85443	reviewed	Kinase
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H6Z9	BXGT020488	Egl nine homolog 3	112399	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NYK1	BXGT021258	Toll-like receptor 7	51284	reviewed
Q9NYZ4	BXGT021265	Sialic acid-binding Ig-like lectin 8	27181	reviewed	Receptor
Q9P1W9	BXGT021296	Serine/threonine-protein kinase pim-2	11040	reviewed	Kinase
Q9UDX4	BXGT021669	SEC14-like protein 3	266629	reviewed
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UP65	BXGT021795	Cytosolic phospholipase A2 gamma	8605	reviewed	Enzyme
Q9Y239	BXGT022213	Nucleotide-binding oligomerization domain-containing protein 1	10392	reviewed	Enzyme
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y5X9	BXGT022307	Endothelial lipase	9388	reviewed	Enzyme
P20036	BXGT022764	HLA class II histocompatibility antigen, DP alpha 1 chain	3113	reviewed	Immune response
P15509	BXGT022826	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha	1438	reviewed	Signaling
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
Q92878	BXGT023071	DNA repair protein RAD50	10111	reviewed
Q8TBZ3	BXGT023141	WD repeat-containing protein 20	91833	reviewed
Q9UM82	BXGT023181	Spermatogenesis-associated protein 2	9825	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P15260	BXGT023924	Interferon gamma receptor 1	3459	reviewed	Receptor
Q6ZTQ4	BXGT025244	Cadherin-related family member 3	222256	reviewed
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator
P21731	BXGT026174	Thromboxane A2 receptor	6915	reviewed	G-protein coupled receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}