adisease

Showing entry for Arthropathy

General Disease Information
BXGD Id	BXGD001544
Disease Name	Arthropathy
Disease CUI Id	C0022408
MeSH Codes	C05
Disease Class Name	Musculoskeletal Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000924
Human Phenotype Ontology Term	Abnormality of the skeletal system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O75173	BXGT005105	A disintegrin and metalloproteinase with thrombospondin motifs 4	9507	reviewed	Enzyme
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
P00451	BXGT005545	Coagulation factor VIII	2157	reviewed	Enzyme
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05186	BXGT006338	Alkaline phosphatase, tissue-nonspecific isozyme	249	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09238	BXGT006875	Stromelysin-2	4319	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13647	BXGT007937	Keratin, type II cytoskeletal 5	3852	reviewed
P14616	BXGT008026	Insulin receptor-related protein	3645	reviewed	Kinase
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P19883	BXGT008528	Follistatin	10468	reviewed	Enzyme modulator
P23219	BXGT008837	Prostaglandin G/H synthase 1	5742	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P27352	BXGT009174	Cobalamin binding intrinsic factor	2694	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28702	BXGT009287	Retinoic acid receptor RXR-beta	6257	reviewed	Nuclear receptor
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P35247	BXGT009804	Pulmonary surfactant-associated protein D	6441	reviewed	Surfactant
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36894	BXGT009939	Bone morphogenetic protein receptor type-1A	657	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40189	BXGT010164	Interleukin-6 receptor subunit beta	3572	reviewed	Signaling
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P49747	BXGT010732	Cartilage oligomeric matrix protein	1311	reviewed
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P55774	BXGT011124	C-C motif chemokine 18	6362	reviewed	Signaling
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P63316	BXGT011517	Troponin C, slow skeletal and cardiac muscles	7134	reviewed	Calcium-binding protein
P80075	BXGT011876	C-C motif chemokine 8	6355	reviewed	Signaling
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P81172	BXGT011935	Hepcidin	57817	reviewed
Q04771	BXGT012783	Activin receptor type-1	90	reviewed	Kinase
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q15113	BXGT013538	Procollagen C-endopeptidase enhancer 1	5118	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q6ZMJ4	BXGT016628	Interleukin-34	146433	reviewed
Q6ZVN8	BXGT016641	Hemojuvelin	148738	reviewed
Q8IU54	BXGT018331	Interferon lambda-1	282618	reviewed
Q8TDU6	BXGT018814	G-protein coupled bile acid receptor 1	151306	reviewed	G-protein coupled receptor
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NX01	BXGT021241	Thioredoxin-like protein 4B	54957	reviewed
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9UNA0	BXGT021784	A disintegrin and metalloproteinase with thrombospondin motifs 5	11096	reviewed	Enzyme
Q9Y2J8	BXGT022237	Protein-arginine deiminase type-2	11240	reviewed
Q9Y3Z3	BXGT022268	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	25939	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed
Q9UIJ7	BXGT026029	GTP:AMP phosphotransferase AK3, mitochondrial	50808	reviewed	Kinase
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}