Showing entry for Transient receptor potential cation channel subfamily M member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018806
Protein NameTransient receptor potential cation channel subfamily M member 4
Uniport IdQ8TD43
GeneTRPM4
Gene Id54795
DomainIon_trans; LSDAT_euk
Pfam PF00520   PF18139  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0071318 cellular response to ATP
Biological Process GO:0002407 dendritic cell chemotaxis
Biological Process GO:0098662 inorganic cation transmembrane transport
Biological Process GO:0086045 membrane depolarization during AV node cell action potential
Biological Process GO:0086048 membrane depolarization during bundle of His cell action potential
Biological Process GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
Biological Process GO:0030502 negative regulation of bone mineralization
Biological Process GO:0045668 negative regulation of osteoblast differentiation
Biological Process GO:1904179 positive regulation of adipose tissue development
Biological Process GO:1903949 positive regulation of atrial cardiac muscle cell action potential
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0045600 positive regulation of fat cell differentiation
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:1904199 positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0002724 regulation of T cell cytokine production
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0098719 sodium ion import across plasma membrane
Biological Process GO:0042310 vasoconstriction
molecular function GO:0005524 ATP binding
molecular function GO:0005227 calcium activated cation channel activity
molecular function GO:0005262 calcium channel activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0042802 identical protein binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0034706 sodium channel complex
cellular component GO:0089717 spanning component of membrane
cellular component GO:0044214 spanning component of plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-3295583 TRP channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006384 BXGD000395 Bundle-Branch Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018794 BXGD001222 Heart Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030591 BXGD002247 Paroxysmal ventricular tachycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037052 BXGD002662 Sick Sinus Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039240 BXGD002804 Supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085614 BXGD003205 First degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151878 BXGD003495 Prolonged QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155707 BXGD003813 Trifascicular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0241148 BXGD005081 Cutaneous plaque
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264912 BXGD005435 Left anterior fascicular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0265961 BXGD005589 Erythrokeratodermia variabilis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0282612 BXGD006820 Prostatic Intraepithelial Neoplasias Neoplasms
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0520878 BXGD009117 Shortened PR interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0520886 BXGD009118 ST segment elevation (finding) Cardiovascular Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600228 BXGD009699 Cardiopulmonary Arrest Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1739135 BXGD013733 Progression of prostate cancer
C1879286 BXGD016570 Hereditary bundle branch system defect Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1970298 BXGD016832 Progressive Familial Heart Block, Type Ib Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2215995 BXGD016947 electrocardiogram - left anterior hemiblock
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3715208 BXGD019451 AV Block First Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0027374 Glyburide 493.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein