Showing entry for Eukaryotic translation initiation factor 2-alpha kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020113
Protein NameEukaryotic translation initiation factor 2-alpha kinase 1
Uniport IdQ9BQI3
GeneEIF2AK1
Gene Id27102
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0055072 iron ion homeostasis
Biological Process GO:0030225 macrophage differentiation
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0046986 negative regulation of hemoglobin biosynthetic process
Biological Process GO:0045993 negative regulation of translational initiation by iron
Biological Process GO:0006909 phagocytosis
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0046501 protoporphyrinogen IX metabolic process
Biological Process GO:0010999 regulation of eIF2 alpha phosphorylation by heme
Biological Process GO:1990641 response to iron ion starvation
molecular function GO:0005524 ATP binding
molecular function GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
molecular function GO:0020037 heme binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
cellular component GO:0005737 cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002879 BXGD000138 Anemia, Hemolytic, Acquired Hemic and Lymphatic Diseases
C0002889 BXGD000146 Anemia, Microangiopathic Hemic and Lymphatic Diseases
C0003431 BXGD000190 Antisocial Personality Disorder Mental Disorders
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0008533 BXGD000556 Hemophilia B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019045 BXGD001269 Hemoglobinopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0023860 BXGD001708 Listeriosis Infections
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0042693 BXGD002996 Violence
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0157738 BXGD003861 Chronic skin ulcer Skin and Connective Tissue Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0221021 BXGD004368 Microangiopathic hemolytic anemia Hemic and Lymphatic Diseases
C0262975 BXGD005273 Chronic dermatitis Skin and Connective Tissue Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0272322 BXGD006343 Severe hereditary factor VIII deficiency disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424101 BXGD008519 Inattention
C0427460 BXGD008616 Red cell distribution width determination
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0472767 BXGD008918 Beta thalassemia intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0476480 BXGD008995 Physical violence
C0677932 BXGD009736 Progressive Neoplastic Disease
C0680458 BXGD009781 Recidivism
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539781 BXGD019086 Progressive cGVHD
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein