Showing entry for O-phosphoseryl-tRNA(Sec) selenium transferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020542
Protein NameO-phosphoseryl-tRNA(Sec) selenium transferase
Uniport IdQ9HD40
GeneSEPSECS
Gene Id51091
DomainSepSecS
Pfam PF05889  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.6 Metabolism of other amino acids hsa00450 Selenocompound metabolism
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001514 selenocysteine incorporation
Biological Process GO:0016259 selenocysteine metabolic process
Biological Process GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
molecular function GO:0016785 transferase activity, transferring selenium-containing groups
molecular function GO:0000049 tRNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-2408557 Selenocysteine synthesis
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009024 BXGD000578 Clonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015310 BXGD000976 Exotropia Eye Diseases; Nervous System Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023882 BXGD001710 Little's Disease Nervous System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038450 BXGD002759 Stridor Pathological Conditions, Signs and Symptoms
C0043094 BXGD003026 Weight Gain Pathological Conditions, Signs and Symptoms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151891 BXGD003499 Retinal depigmentation Pathological Conditions, Signs and Symptoms; Eye Diseases; Skin and Connective Tissue Diseases
C0232462 BXGD004542 Decrease in appetite Digestive System Diseases; Nervous System Diseases; Mental Disorders
C0232466 BXGD004543 Feeding difficulties
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239815 BXGD004996 Hand clenching
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0262665 BXGD005267 Abnormal vocal cord morphology
C0266468 BXGD005677 Congenital pontocerebellar hypoplasia Nervous System Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0276434 BXGD006424 Acute type A viral hepatitis Digestive System Diseases; Infections
C0332615 BXGD006898 Myopathic facies
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0740279 BXGD009973 Cerebellar atrophy
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1321325 BXGD012429 Elliptical nystagmus Eye Diseases; Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1837397 BXGD014227 Severe global developmental delay
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1843367 BXGD014576 Poor school performance
C1850055 BXGD015102 PEHO syndrome Eye Diseases; Nervous System Diseases
C1850056 BXGD015103 Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome Eye Diseases; Nervous System Diseases
C1850456 BXGD015146 Progressive microcephaly
C1855330 BXGD015487 Cerebral hypoplasia
C1858025 BXGD015760 Spinal rigidity
C1969879 BXGD016799 Limb joint contracture
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2673431 BXGD017202 Abnormality of the periventricular white matter Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2677328 BXGD017371 Cerebral hypomyelination
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2932714 BXGD018099 Pontocerebellar Hypoplasia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3151140 BXGD018399 PONTOCEREBELLAR HYPOPLASIA, TYPE 2D
C3161330 BXGD018511 Profound intellectual disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808046 BXGD019538 Breathing dysregulation
C3808249 BXGD019541 Abnormality of the optic disc
C3887784 BXGD019920 Decreased urine output
C4021216 BXGD020580 EEG with persistent abnormal rhythmic activity
C4023342 BXGD021158 Gastrostomy tube feeding in infancy
C4025701 BXGD021741 Abnormality of the cerebral cortex
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4048329 BXGD021904 Immunosuppression
C4552810 BXGD023525 Irritability, CTCAE
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0027821 4-deoxypyridoxine 5'-phosphate 233.05
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein