Showing entry for Unconventional myosin-Va


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022278
Protein NameUnconventional myosin-Va
Uniport IdQ9Y4I1
GeneMYO5A
Gene Id4644
DomainDIL; IQ; Myosin_head
Pfam PF01843   PF00612   PF00063  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0007015 actin filament organization
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0099089 establishment of endoplasmic reticulum localization to postsynapse
Biological Process GO:0006887 exocytosis
Biological Process GO:0048820 hair follicle maturation
Biological Process GO:0030073 insulin secretion
Biological Process GO:0031987 locomotion involved in locomotory behavior
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0042438 melanin biosynthetic process
Biological Process GO:0030318 melanocyte differentiation
Biological Process GO:0032402 melanosome transport
Biological Process GO:0042552 myelination
Biological Process GO:0042476 odontogenesis
Biological Process GO:0006892 post-Golgi vesicle-mediated transport
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0031585 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Biological Process GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration
Biological Process GO:0032252 secretory granule localization
Biological Process GO:0050808 synapse organization
Biological Process GO:0016192 vesicle-mediated transport
Biological Process GO:0030050 vesicle transport along actin filament
Biological Process GO:0007601 visual perception
molecular function GO:0030898 actin-dependent ATPase activity
molecular function GO:0051015 actin filament binding
molecular function GO:0005524 ATP binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0097718 disordered domain specific binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000146 microfilament motor activity
molecular function GO:0017137 Rab GTPase binding
molecular function GO:0003723 RNA binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0042641 actomyosin
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0032433 filopodium tip
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005794 Golgi apparatus
cellular component GO:0030426 growth cone
cellular component GO:0032593 insulin-responsive compartment
cellular component GO:0005882 intermediate filament
cellular component GO:0042470 melanosome
cellular component GO:0016020 membrane
cellular component GO:0035371 microtubule plus-end
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0001726 ruffle
cellular component GO:0016461 unconventional myosin complex
Reactome
Pathway Id Pathway Name
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-264876 Insulin processing
R-HSA-2980736 Peptide hormone metabolism
R-HSA-392499 Metabolism of proteins
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9664407 Parasite infection
R-HSA-9664417 Leishmania phagocytosis
R-HSA-9664422 FCGR3A-mediated phagocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001486 BXGD000056 Adenovirus Infections Infections
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0080024 BXGD003104 Piebaldism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0154920 BXGD003755 Pigmentary iris degeneration Eye Diseases; Skin and Connective Tissue Diseases
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0239804 BXGD004995 White hair
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0263498 BXGD005316 Premature canities
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0270685 BXGD006084 Cerebral calcification Nutritional and Metabolic Diseases; Nervous System Diseases
C0276447 BXGD006425 Rhinovirus infection Infections
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398794 BXGD008234 Hypopigmentation-immunodeficiency disease Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0474967 BXGD008965 Spindle cell nevus of Reed Neoplasms
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0878773 BXGD011391 Overactive Bladder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1836573 BXGD014133 GRISCELLI SYNDROME, TYPE 3 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1836576 BXGD014134 Silver-gray hair
C1843389 BXGD014580 Accumulation of melanosomes in melanocytes
C1843390 BXGD014581 Melanin pigment aggregation in hair shafts
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859194 BXGD015860 GRISCELLI SYNDROME, TYPE 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1860157 BXGD015959 Elejalde Disease Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Nervous System Diseases
C1876214 BXGD016567 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3278401 BXGD018739 Hypopigmentation of hair
C3495588 BXGD018997 Acrocephalopolydactylous Dysplasia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4022153 BXGD020884 Cerebral cortical hemiatrophy
C4023018 BXGD021068 Subcortical cerebral atrophy
C4024710 BXGD021381 Cerebellar cortical atrophy
C4024742 BXGD021399 Aplasia/Hypoplasia of the macula
C4024878 BXGD021453 Generalized hyperpigmentation Skin and Connective Tissue Diseases
C4025712 BXGD021748 Abnormality of the cerebellar vermis
C4025790 BXGD021791 Specific learning disability
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein