Showing entry for Mitogen-activated protein kinase kinase kinase 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022340
Protein NameMitogen-activated protein kinase kinase kinase 4
Uniport IdQ9Y6R4
GeneMAP3K4
Gene Id4216
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000186 activation of MAPKK activity
Biological Process GO:0060718 chorionic trophoblast cell differentiation
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0019100 male germ-line sex determination
Biological Process GO:0001890 placenta development
Biological Process GO:0043507 positive regulation of JUN kinase activity
Biological Process GO:1900745 positive regulation of p38MAPK cascade
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:1904355 positive regulation of telomere capping
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0010225 response to UV-C
molecular function GO:0005524 ATP binding
molecular function GO:0004709 MAP kinase kinase kinase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028259 BXGD002073 Nodule
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036875 BXGD002640 Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1868720 BXGD016531 Periventricular Nodular Heterotopia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2930471 BXGD017887 Bilateral Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein