Showing entry for Chloride channel protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023831
Protein NameChloride channel protein 1
Uniport IdP35523
GeneCLCN1
Gene Id1180
DomainVoltage_CLC
Pfam PF00654  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0006821 chloride transport
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006936 muscle contraction
Biological Process GO:0019227 neuronal action potential propagation
Biological Process GO:0034765 regulation of ion transmembrane transport
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0005247 voltage-gated chloride channel activity
cellular component GO:0034707 chloride channel complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0002963 BXGD000161 Angina Pectoris, Variant Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027125 BXGD001975 Myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027127 BXGD001977 Myotonia Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0030196 BXGD002192 Pain in limb Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085655 BXGD003226 Polymyositis Musculoskeletal Diseases; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0154676 BXGD003729 Organic writer's cramp Nervous System Diseases
C0221055 BXGD004382 Paramyotonia Congenita (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234119 BXGD004622 Neuromuscular inhibition
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234664 BXGD004695 Lid lag
C0238357 BXGD004916 Hyperkalemic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0238358 BXGD004917 Hypokalemic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0240310 BXGD005030 Hypoplasia of the maxilla
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0270959 BXGD006140 Myotonia Levior Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0391957 BXGD008019 idiopathic epilepsy
C0410264 BXGD008423 Contracture of tendo achilles
C0426980 BXGD008599 Motor symptoms
C0476403 BXGD008992 Electromyogram abnormal
C0553604 BXGD009402 Myotonic Disorders Musculoskeletal Diseases; Nervous System Diseases
C0751359 BXGD010409 Percussion Myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751360 BXGD010410 Becker Generalized Myotonia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0917713 BXGD011404 Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1563715 BXGD013389 Andersen Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1828221 BXGD013786 Non dystrophic myotonia Musculoskeletal Diseases; Nervous System Diseases
C1837352 BXGD014223 Childhood onset
C1850663 BXGD015169 Muscle hypertrophy of the lower extremities
C1868623 BXGD016517 Handgrip myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1869117 BXGD016550 Paroxysmal nonkinesigenic dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1959600 BXGD016642 Obscure African cardiomyopathy Cardiovascular Diseases
C2265792 BXGD017012 Skeletal muscle hypertrophy
C2931139 BXGD017965 Nondystrophic myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2931826 BXGD018069 Potassium aggravated myotonia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2936781 BXGD018135 Generalized Myotonia of Thomsen Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3887485 BXGD019877 MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021727 BXGD020736 EMG: neuropathic changes
C4022169 BXGD020890 EMG: myotonic discharges
C4022683 BXGD020956 Myotonia of the upper limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4025575 BXGD021673 Myotonia with warm-up phenomenon Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4025576 BXGD021674 EMG: myotonic runs Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316810 BXGD022702 Writer's Cramp Nervous System Diseases
C4551506 BXGD023326 Paroxysmal Nonkinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein