Showing entry for Generalized seizures


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004687
Disease NameGeneralized seizures
Disease CUI IdC0234533
MeSH Codes C23   C10  
Disease Class NamePathological Conditions, Signs and Symptoms; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00142 BXGT003883 Thymidine kinase 2, mitochondrial 7084 reviewed Kinase
O00519 BXGT003934 Fatty-acid amide hydrolase 1 2166 reviewed
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O60462 BXGT004876 Neuropilin-2 8828 reviewed
O60741 BXGT004897 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 348980 reviewed
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O95970 BXGT005409 Leucine-rich glioma-inactivated protein 1 9211 reviewed
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01303 BXGT005748 Pro-neuropeptide Y 4852 reviewed Signaling
P01308 BXGT005749 Insulin 3630 reviewed
P01574 BXGT005768 Interferon beta 3456 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02792 BXGT005966 Ferritin light chain 2512 reviewed Storage
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P05023 BXGT006294 Sodium/potassium-transporting ATPase subunit alpha-1 476 reviewed Transporter
P05108 BXGT006317 Cholesterol side-chain cleavage enzyme, mitochondrial 1583 reviewed
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme 249 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06276 BXGT006430 Cholinesterase 590 reviewed
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P08138 BXGT006729 Tumor necrosis factor receptor superfamily member 16 4804 reviewed Receptor
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08908 BXGT006837 5-hydroxytryptamine receptor 1A 3350 reviewed G-protein coupled receptor
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P10909 BXGT007630 Clusterin 1191 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 1128 reviewed G-protein coupled receptor
P13716 BXGT007948 Delta-aminolevulinic acid dehydratase 210 reviewed Enzyme
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P15311 BXGT008106 Ezrin 7430 reviewed Cellular structure
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P16389 BXGT008221 Potassium voltage-gated channel subfamily A member 2 3737 reviewed Ion channel
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 7364 reviewed
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18089 BXGT008379 Alpha-2B adrenergic receptor 151 reviewed G-protein coupled receptor
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 2566 reviewed Ion channel
P19021 BXGT008449 Peptidyl-glycine alpha-amidating monooxygenase 5066 reviewed Enzyme
P20472 BXGT008578 Parvalbumin alpha 5816 reviewed Calcium-binding protein
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P23946 BXGT008932 Chymase 1215 reviewed Enzyme
P23975 BXGT008935 Sodium-dependent noradrenaline transporter 6530 reviewed Transporter
P24666 BXGT008986 Low molecular weight phosphotyrosine protein phosphatase 52 reviewed
P24752 BXGT008993 Acetyl-CoA acetyltransferase, mitochondrial 38 reviewed Enzyme
P25713 BXGT009062 Metallothionein-3 4504 reviewed
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28222 BXGT009238 5-hydroxytryptamine receptor 1B 3351 reviewed G-protein coupled receptor
P28329 BXGT009251 Choline O-acetyltransferase 1103 reviewed Enzyme
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 2562 reviewed Ion channel
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29218 BXGT009322 Inositol monophosphatase 1 3612 reviewed Enzyme
P29274 BXGT009327 Adenosine receptor A2a 135 reviewed G-protein coupled receptor
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30531 BXGT009432 Sodium- and chloride-dependent GABA transporter 1 6529 reviewed Transporter
P30532 BXGT009433 Neuronal acetylcholine receptor subunit alpha-5 1138 reviewed Ion channel
P30874 BXGT009475 Somatostatin receptor type 2 6752 reviewed G-protein coupled receptor
P30926 BXGT009482 Neuronal acetylcholine receptor subunit beta-4 1143 reviewed Ion channel
P31644 BXGT009557 Gamma-aminobutyric acid receptor subunit alpha-5 2558 reviewed Ion channel
P32297 BXGT009616 Neuronal acetylcholine receptor subunit alpha-3 1136 reviewed Ion channel
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35368 BXGT009822 Alpha-1B adrenergic receptor 147 reviewed G-protein coupled receptor
P35372 BXGT009823 Mu-type opioid receptor 4988 reviewed G-protein coupled receptor
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha 6323 reviewed Ion channel
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P39086 BXGT010093 Glutamate receptor ionotropic, kainate 1 2897 reviewed Ion channel
P41145 BXGT010225 Kappa-type opioid receptor 4986 reviewed G-protein coupled receptor
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P43005 BXGT010349 Excitatory amino acid transporter 3 6505 reviewed Transporter
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P45381 BXGT010460 Aspartoacylase 443 reviewed
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P49591 BXGT010715 Serine--tRNA ligase, cytoplasmic 6301 reviewed Enzyme
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P50135 BXGT010776 Histamine N-methyltransferase 3176 reviewed
P51159 BXGT010839 Ras-related protein Rab-27A 5873 reviewed
P53985 BXGT011022 Monocarboxylate transporter 1 6566 reviewed Transporter
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P80404 BXGT011907 4-aminobutyrate aminotransferase, mitochondrial 18 reviewed Enzyme
Q05329 BXGT012814 Glutamate decarboxylase 2 2572 reviewed Enzyme
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q11203 BXGT013218 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 6487 reviewed
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14108 BXGT013440 Lysosome membrane protein 2 950 reviewed Receptor
Q14353 BXGT013463 Guanidinoacetate N-methyltransferase 2593 reviewed
Q14654 BXGT013495 ATP-sensitive inward rectifier potassium channel 11 3767 reviewed Ion channel
Q14721 BXGT013502 Potassium voltage-gated channel subfamily B member 1 3745 reviewed Ion channel
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q5VZ30 BXGT015894 Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa) 2572 unreviewed
Q8IVS2 BXGT018349 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial 27349 reviewed
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q96SW2 BXGT019743 Protein cereblon 51185 reviewed Enzyme
Q96T60 BXGT019745 Bifunctional polynucleotide phosphatase/kinase 11284 reviewed
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q9H2X9 BXGT020459 Solute carrier family 12 member 5 57468 reviewed Transporter
Q9H8M5 BXGT020496 Metal transporter CNNM2 54805 reviewed
Q9NW15 BXGT021229 Anoctamin-10 55129 reviewed
Q9NWB1 BXGT021231 RNA binding protein fox-1 homolog 1 54715 reviewed Nucleic acid binding
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B 10765 reviewed Epigenetic regulator
Q9UGM6 BXGT021687 Tryptophan--tRNA ligase, mitochondrial 10352 reviewed
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase 23043 reviewed Kinase
Q9UKM7 BXGT021747 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 11253 reviewed Chaperone
Q9UL51 BXGT021754 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 610 reviewed Ion channel
Q9ULC4 BXGT021757 Malignant T-cell-amplified sequence 1 28985 reviewed Receptor
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha 6334 reviewed Ion channel
Q9Y263 BXGT022220 Phospholipase A-2-activating protein 9373 reviewed Enzyme modulator
Q9Y3Q4 BXGT022264 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 10021 reviewed Ion channel
Q96C86 BXGT022803 m7GpppX diphosphatase 28960 reviewed Enzyme
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P35523 BXGT023831 Chloride channel protein 1 1180 reviewed Ion channel
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q8TAB3 BXGT025819 Protocadherin-19 57526 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease