Showing entry for Probable tRNA N6-adenosine threonylcarbamoyltransferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024113
Protein NameProbable tRNA N6-adenosine threonylcarbamoyltransferase
Uniport IdQ9NPF4
GeneOSGEP
Gene Id55644
DomainPeptidase_M22
Pfam PF00814  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002949 tRNA threonylcarbamoyladenosine modification
molecular function GO:0046872 metal ion binding
molecular function GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0000408 EKC/KEOPS complex
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-6782315 tRNA modification in the nucleus and cytosol
R-HSA-72306 tRNA processing
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003706 BXGD000215 Arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0079924 BXGD003103 Oligohydramnios Female Urogenital Diseases and Pregnancy Complications
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0221369 BXGD004453 Acquired Camptodactyly
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266483 BXGD005680 Pachygyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0268747 BXGD006034 Diffuse mesangial sclerosis (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0349588 BXGD007933 Short stature
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0403397 BXGD008277 Steroid-resistant nephrotic syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424711 BXGD008541 Orbital separation diminished
C0431350 BXGD008668 Primary microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0678230 BXGD009750 Congenital Epicanthus
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0795949 BXGD010768 Galloway Mowat syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Nervous System Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1704380 BXGD013555 Distal Renal Tubular Acidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1737329 BXGD013728 Dysmorphism Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1839758 BXGD014402 Narrow forehead
C1853242 BXGD015322 Midface retrusion
C1855433 BXGD015496 Mandibulofacial dysostosis, Treacher Collins type, autosomal recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C1857679 BXGD015735 Sloping forehead
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1862322 BXGD016123 Ovalocytosis, Malaysian-Melanesian-Filipino Type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1864498 BXGD016233 RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2749675 BXGD017631 Cortical gyral simplification
C2919142 BXGD017867 Short Stature, CTCAE
C2936786 BXGD018137 Aqueductal Stenosis Nervous System Diseases
C3266102 BXGD018597 Steroid resistant nephrotic syndrome of childhood Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3489393 BXGD018928 Hiatal Hernia Pathological Conditions, Signs and Symptoms
C3554617 BXGD019228 Adducted thumb Musculoskeletal Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021986 BXGD020858 Hypoplasia of the ear cartilage
C4023616 BXGD021229 Abnormality of immune system physiology
C4025249 BXGD021604 Abnormality of the intervertebral disk
C4540266 BXGD023249 GALLOWAY-MOWAT SYNDROME 3
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein