Showing entry for Tau-tubulin kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025689
Protein NameTau-tubulin kinase 2
Uniport IdQ6IQ55
GeneTTBK2
Gene Id146057
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0021681 cerebellar granular layer development
Biological Process GO:0021935 cerebellar granule cell precursor tangential migration
Biological Process GO:0021549 cerebellum development
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0060271 cilium assembly
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:1904527 negative regulation of microtubule binding
Biological Process GO:0007026 negative regulation of microtubule depolymerization
Biological Process GO:1902817 negative regulation of protein localization to microtubule
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0007224 smoothened signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0019894 kinesin binding
molecular function GO:0051010 microtubule plus-end binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0048156 tau protein binding
molecular function GO:0050321 tau-protein kinase activity
cellular component GO:0005814 centriole
cellular component GO:0036064 ciliary basal body
cellular component GO:0035869 ciliary transition zone
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005615 extracellular space
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0037952 BXGD002719 Spinocerebellar Degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0202236 BXGD004086 Triglycerides measurement
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0271386 BXGD006194 Vertical Nystagmus Eye Diseases; Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0392885 BXGD008071 High density lipoprotein measurement
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0752120 BXGD010668 Spinocerebellar Ataxia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752122 BXGD010670 Spinocerebellar Ataxia Type 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752124 BXGD010672 Spinocerebellar Ataxia Type 6 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836150 BXGD014082 Gait imbalance
C1853558 BXGD015344 Jerky ocular pursuit movements
C1858351 BXGD015783 SPINOCEREBELLAR ATAXIA 11 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1866751 BXGD016422 Spinocerebellar tract degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein