Showing entry for Frontotemporal dementia


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007176
Disease NameFrontotemporal dementia
Disease CUI IdC0338451
MeSH Codes C18   C10   F03  
Disease Class NameNutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id DOID:630   DOID:7   DOID:150  
Disease Ontology Class Namegenetic disease; disease of anatomical entity; disease of mental health
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00187 BXGT003890 Mannan-binding lectin serine protease 2 10747 reviewed Enzyme
O00311 BXGT003908 Cell division cycle 7-related protein kinase 8317 reviewed Kinase
O00451 BXGT003923 GDNF family receptor alpha-2 2675 reviewed
O00571 BXGT003938 ATP-dependent RNA helicase DDX3X 1654 reviewed
O14578 BXGT004072 Citron Rho-interacting kinase 11113 reviewed Kinase
O14980 BXGT004119 Exportin-1 7514 reviewed Receptor
O15269 BXGT004145 Serine palmitoyltransferase 1 10558 reviewed Enzyme
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O43612 BXGT004605 Orexin 3060 reviewed
O60341 BXGT004873 Lysine-specific histone demethylase 1A 23028 reviewed Epigenetic regulator
O94811 BXGT005336 Tubulin polymerization-promoting protein 11076 reviewed Cellular structure
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95819 BXGT005398 Mitogen-activated protein kinase kinase kinase kinase 4 9448 reviewed Kinase
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01303 BXGT005748 Pro-neuropeptide Y 4852 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02654 BXGT005911 Apolipoprotein C-I 341 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03886 BXGT006108 NADH-ubiquinone oxidoreductase chain 1 4535 reviewed Enzyme
P03951 BXGT006117 Coagulation factor XI 2160 reviewed Enzyme
P04156 BXGT006156 Major prion protein 5621 reviewed
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05090 BXGT006311 Apolipoprotein D 347 reviewed
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P06276 BXGT006430 Cholinesterase 590 reviewed
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07602 BXGT006646 Prosaposin 5660 reviewed
P07737 BXGT006663 Profilin-1 5216 reviewed
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08397 BXGT006768 Porphobilinogen deaminase 3145 reviewed Enzyme
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 3178 reviewed
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22626 BXGT008787 Heterogeneous nuclear ribonucleoproteins A2/B1 3181 reviewed
P23246 BXGT008840 Splicing factor, proline- and glutamine-rich 6421 reviewed Nucleic acid binding
P23378 BXGT008859 Glycine dehydrogenase (decarboxylating), mitochondrial 2731 reviewed Enzyme
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P25705 BXGT009060 ATP synthase subunit alpha, mitochondrial 498 reviewed Transporter
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28331 BXGT009252 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 4719 reviewed Enzyme
P28347 BXGT009257 Transcriptional enhancer factor TEF-1 7003 reviewed Transcription factor
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P31943 BXGT009587 Heterogeneous nuclear ribonucleoprotein H 3187 reviewed Nucleic acid binding
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P34998 BXGT009781 Corticotropin-releasing factor receptor 1 1394 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40199 BXGT010166 Carcinoembryonic antigen-related cell adhesion molecule 6 4680 reviewed
P42263 BXGT010295 Glutamate receptor 3 2892 reviewed Ion channel
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42575 BXGT010318 Caspase-2 835 reviewed Enzyme
P42658 BXGT010327 Dipeptidyl aminopeptidase-like protein 6 1804 reviewed Enzyme
P42858 BXGT010341 Huntingtin 3064 reviewed
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 2561 reviewed Ion channel
P48730 BXGT010656 Casein kinase I isoform delta 1453 reviewed Kinase
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 7182 reviewed Nuclear receptor
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49792 BXGT010743 E3 SUMO-protein ligase RanBP2 5903 reviewed Enzyme modulator
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P52758 BXGT010951 2-iminobutanoate/2-iminopropanoate deaminase 10247 reviewed
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P53634 BXGT011007 Dipeptidyl peptidase 1 1075 reviewed Enzyme
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55786 BXGT011125 Puromycin-sensitive aminopeptidase 9520 reviewed Enzyme
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P62826 BXGT011463 GTP-binding nuclear protein Ran 5901 reviewed Enzyme modulator
P63165 BXGT011506 Small ubiquitin-related modifier 1 7341 reviewed
P68366 BXGT011595 Tubulin alpha-4A chain 7277 reviewed Cellular structure
P78330 BXGT011833 Phosphoserine phosphatase 5723 reviewed Enzyme
P78344 BXGT011835 Eukaryotic translation initiation factor 4 gamma 2 1982 reviewed Nucleic acid binding
P78563 BXGT011850 Double-stranded RNA-specific editase 1 104 reviewed Enzyme
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P99999 BXGT012235 Cytochrome c 54205 reviewed
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit 4791 reviewed Transcription factor
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q05940 BXGT012846 Synaptic vesicular amine transporter 6571 reviewed Transporter
Q06418 BXGT012875 Tyrosine-protein kinase receptor TYRO3 7301 reviewed Kinase
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q08170 BXGT012962 Serine/arginine-rich splicing factor 4 6429 reviewed Nucleic acid binding
Q12840 BXGT013269 Kinesin heavy chain isoform 5A 3798 reviewed Cellular structure
Q13137 BXGT013316 Calcium-binding and coiled-coil domain-containing protein 2 10241 reviewed
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13231 BXGT013329 Chitotriosidase-1 1118 reviewed
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q13546 BXGT013372 Receptor-interacting serine/threonine-protein kinase 1 8737 reviewed Kinase
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q14315 BXGT013460 Filamin-C 2318 reviewed
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 8851 reviewed Enzyme modulator
Q15233 BXGT013552 Non-POU domain-containing octamer-binding protein 4841 reviewed Nucleic acid binding
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15366 BXGT013559 Poly(rC)-binding protein 2 5094 reviewed Enzyme
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q5JTZ9 BXGT015458 Alanine--tRNA ligase, mitochondrial 57505 reviewed Nucleic acid binding
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q6P4F1 BXGT016448 Alpha-(1,3)-fucosyltransferase 10 84750 reviewed Enzyme
Q86X55 BXGT017627 Histone-arginine methyltransferase CARM1 10498 reviewed Epigenetic regulator
Q96HC4 BXGT019671 PDZ and LIM domain protein 5 10611 reviewed Cellular structure
Q99523 BXGT019929 Sortilin 6272 reviewed Transporter
Q99558 BXGT019934 Mitogen-activated protein kinase kinase kinase 14 9020 reviewed Kinase
Q99574 BXGT019936 Neuroserpin 5274 reviewed Enzyme modulator
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q9HCE7 BXGT020532 E3 ubiquitin-protein ligase SMURF1 57154 reviewed Enzyme
Q9NPG3 BXGT021156 Ubinuclein-1 29855 reviewed
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 55775 reviewed Enzyme
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9P2R7 BXGT021304 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial 8803 reviewed Enzyme
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UKA9 BXGT021740 Polypyrimidine tract-binding protein 2 58155 reviewed
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase 23043 reviewed Kinase
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha 815 reviewed Kinase
Q9Y223 BXGT022207 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 10020 reviewed Enzyme
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 26013 reviewed Epigenetic regulator
P09622 BXGT023116 Dihydrolipoyl dehydrogenase, mitochondrial 1738 reviewed Enzyme
P57729 BXGT024172 Ras-related protein Rab-38 23682 reviewed
O14966 BXGT024179 Ras-related protein Rab-7L1 8934 reviewed
O94923 BXGT024255 D-glucuronyl C5-epimerase 26035 reviewed
Q6SZW1 BXGT025034 NAD(+) hydrolase SARM1 23098 reviewed
Q6IQ55 BXGT025689 Tau-tubulin kinase 2 146057 reviewed Kinase
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease