Showing entry for Rho guanine nucleotide exchange factor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026130
Protein NameRho guanine nucleotide exchange factor 1
Uniport IdQ92888
GeneARHGEF1
Gene Id9138
DomainPH_16; RGS-like; RhoGEF
Pfam PF17838   PF09128   PF00621  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007266 Rho protein signal transduction
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0005089 Rho guanyl-nucleotide exchange factor activity
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-73887 Death Receptor Signalling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006267 BXGD000383 Bronchiectasis Respiratory Tract Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0020541 BXGD001424 Portal Hypertension Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023652 BXGD001691 Lichen Sclerosus et Atrophicus Skin and Connective Tissue Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027822 BXGD002045 Neurodermatitis Skin and Connective Tissue Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0149922 BXGD003386 Lichen Simplex Chronicus Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220621 BXGD004300 Childhood Acute Myeloid Leukemia Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0272187 BXGD006318 Congenital leukocyte adherence deficiency
C0275551 BXGD006379 Primary bacterial peritonitis Digestive System Diseases; Infections
C0280449 BXGD006746 secondary acute myeloid leukemia Neoplasms
C0346210 BXGD007802 Vulval intraepithelial neoplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4743661 BXGD023935 Leukocyte Adhesion Deficiency Type 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005350 Dehydroaporheine 277.32
BXGC0039975 Noraristolodione 293.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein