Showing entry for Chrysophanol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001881
Compound NameChrysophanol
Structure
FormulaC15H10O4
InchiKeyLQGUBLBATBMXHT-UHFFFAOYSA-N
SMILESCC1=CC2=C(C(O)=C1)C(=O)C1=C(C=CC=C1O)C2=O
InchiInChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
IUPAC1,8-dihydroxy-3-methyl-9,10-dihydroanthracene-9,10-dione
Molecular Weight254.24
Pubchem Id10208
Chembl IdCHEMBL41092
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50455992
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006756 Neutrophil elastase reviewed Enzyme ELANE - 18000 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 46210 - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 - 36120 - -
reviewed BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed Txnrd1 - 194000 - -
reviewed BXGT022399 Thioredoxin reductase 2, mitochondrial reviewed Txnrd2 - 181000 - -
CHEMBL CHEMBL41092
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 25118 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 '=' 18000 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Inhibition '=' 39 %
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 15848 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 118 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 118 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 12589 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 46210 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 12589 nM
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 Inhibition '=' 38 %
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 25118 nM
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Inhibition '=' 13 %
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 0 pm/min/mg
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 79432 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Inhibition - - -
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si Inhibition - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 128 %
Q9Z0J5 BXGT022399 Thioredoxin reductase 2, mitochondrial reviewed - Txnrd2 IC50 '=' 181000 nM
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Ki '>' 10000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 2818 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 25118 nM
P16234 BXGT008209 Platelet-derived growth factor receptor alpha reviewed Kinase PDGFRA Activity - - -
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB Activity - - -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 124 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 124 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 25118 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 63095 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 93 %
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 36120 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 3162 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency '=' 39810 nM
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 reviewed Enzyme AKR1B10 Inhibition - - -
P00766 BXGT005647 Chymotrypsinogen A reviewed - Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '=' 111 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '=' 111 %
P08419 BXGT006770 Chymotrypsin-like elastase family member 2A reviewed - CELA2A Inhibition - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Inhibition '=' 79 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 3162 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Inhibition '=' 42 %
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 6682 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 26603 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 IC50 '=' 194000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 19952 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 2238 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 7079 nM
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 Inhibition - - -
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 reviewed Enzyme AKR1A1 Inhibition - - -
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 31622 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 14125 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 29 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00111 Cornmint Mentha arvensis Herbs and Spices
BXGF00154 Garden rhubarb Rheum rhabarbarum Vegetables
BXGF00164 Sorrel Rumex acetosa Herbs and Spices
BXGF00323 Dock Rumex Herbs and Spices
BXGF00459 Wax gourd Benincasa hispida Gourds
BXGF00892 Leptocereus quadricostatus Leptocereus quadricostatus Others
BXGF00896 Magnolia figo Magnolia figo Human Edible Plant
BXGF00910 Glechoma longituba Glechoma longituba Medicinal Plant
BXGF00919 Chaiturus marrubiastrum Chaiturus marrubiastrum Others
BXGF00981 Flacourtia jangomas Flacourtia jangomas Medicinal Plant
BXGF01126 Polygonum cuspidatum Polygonum cuspidatum Medicinal Plant
BXGF01185 Aloe vera Aloe vera Medicinal Plant
BXGF01187 Onobrychis arenaria Onobrychis arenaria Others
BXGF01223 Eria mollis Eria mollis Others
BXGF01302 Dysoxylum cumingianum Dysoxylum cumingianum Others
BXGF01307 Hemerocallis radix Hemerocallis radix Others
BXGF01311 Aizopsis selskiana Aizopsis selskiana Others
BXGF01344 Psychotria stachyoides Psychotria stachyoides Others
BXGF01357 Ampelopsis japonica Ampelopsis japonica Medicinal Plant
BXGF01391 Dodonaea viscosa Dodonaea viscosa Medicinal Plant
BXGF01495 Pleione yunnanensis Pleione yunnanensis Others
BXGF01529 Rhamnus davurica Rhamnus davurica Medicinal Plant
BXGF01541 Rumex patientia Rumex patientia Medicinal Plant
BXGF01568 Teucrium yemense Teucrium yemense Others
BXGF01570 Pinalia stricta Pinalia stricta Others
BXGF01623 Amphorogyne spicata Amphorogyne spicata Others
BXGF01641 Neobalanocarpus heimii Neobalanocarpus heimii Others
BXGF01683 Aconitum tasiromontanum Aconitum tasiromontanum Others
BXGF01695 Tanacetum coccineum Tanacetum coccineum Medicinal Plant
BXGF01716 Mentha canadensis Mentha canadensis Medicinal Plant
BXGF01764 Dendriopoterium menendezii Dendriopoterium menendezii Others
BXGF01771 Achyranthes fauriei Achyranthes fauriei Medicinal Plant
BXGF01794 Adansonia grandidieri Adansonia grandidieri Human Edible Plant
BXGF01799 Mandragora autumnalis Mandragora autumnalis Medicinal Plant
BXGF01812 Physalis alkekengi Physalis alkekengi Medicinal Plant
BXGF01836 Aphyllocladus denticulatus Aphyllocladus denticulatus Others
BXGF01850 Bassia muricata Bassia muricata Medicinal Plant
BXGF01900 Aloe ferox Aloe ferox Medicinal Plant
BXGF01931 Dalbergia lanceolaria subsp. paniculata Dalbergia lanceolaria subsp. paniculata Medicinal Plant
BXGF01947 Senecio subdentatus Senecio subdentatus Others
BXGF01960 Achyranthes bidentata Achyranthes bidentata Medicinal Plant
BXGF02006 Aconitum seravschanicum Aconitum seravschanicum Others
BXGF02037 Carduus tenuiflorus Carduus tenuiflorus Others
BXGF02203 Verbascum thapsiforme Verbascum thapsiforme Medicinal Plant
BXGF02256 Rumex chalepensis Rumex chalepensis Others
BXGF02289 Rhododendron dahuricum Rhododendron dahuricum Others
BXGF02323 Dalbergia hupeana Dalbergia hupeana Medicinal Plant
BXGF02357 Euodia bodinieri Euodia bodinieri Others
BXGF02387 Salvia greggii Salvia greggii Medicinal Plant
BXGF02496 Pleione bulbocodioides Pleione bulbocodioides Others
BXGF02499 Cremastra appendiculata Cremastra appendiculata Medicinal Plant
BXGF02503 Balanophora laxiflora Balanophora laxiflora Others
BXGF02528 Cirsium oligophyllum Cirsium oligophyllum Medicinal Plant
BXGF02548 Hemerocallis fulva Hemerocallis fulva Medicinal Plant
BXGF02566 Fridericia triplinervia Fridericia triplinervia Others
BXGF02576 Anaphalis lactea Anaphalis lactea Others
BXGF02632 Metrodorea nigra Metrodorea nigra Others
BXGF02662 Rheum wittrocki Rheum wittrocki Medicinal Plant
BXGF02724 Tectona grandis Tectona grandis Medicinal Plant
BXGF02814 Senecio praecox Senecio praecox Others
BXGF02815 Pinellia ternata Pinellia ternata Medicinal Plant
BXGF02817 Garcinia polyantha Garcinia polyantha Medicinal Plant
BXGF02853 Anchusa azurea Anchusa azurea Medicinal Plant
BXGF02880 Nepeta granatensis Nepeta granatensis Others
BXGF02900 Gleichenia quadripartita Gleichenia quadripartita Others
BXGF02932 Dipsacus azureus Dipsacus azureus Others
BXGF02958 Jacquemontia paniculata Jacquemontia paniculata Others
BXGF02978 Tetradium ruticarpum Tetradium ruticarpum Medicinal Plant
BXGF02993 Caulerpa peltata Caulerpa peltata Human Edible Plant
BXGF03028 Lespedeza tomentosa Lespedeza tomentosa Medicinal Plant
BXGF03042 Rosa pomifera Rosa pomifera Human Edible Plant
BXGF03064 Degenia velebitica Degenia velebitica Others
BXGF03077 Albizia myriophylla Albizia myriophylla Medicinal Plant
BXGF03088 Erythrophleum ivorense Erythrophleum ivorense Medicinal Plant
BXGF03114 Delphinium virgatum Delphinium virgatum Others
BXGF03135 Grangea maderaspatana Grangea maderaspatana Medicinal Plant
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03167 Tagetes filifolia Tagetes filifolia Medicinal Plant
BXGF03217 Delphinium nuttallianum Delphinium nuttallianum Others
BXGF03251 Lupinus corymbosus Lupinus corymbosus Others
BXGF03298 Senecio behnii Senecio behnii Others
BXGF03317 Dillenia indica Dillenia indica Medicinal Plant
BXGF03436 Photinia serratifolia Photinia serratifolia Medicinal Plant
BXGF03485 Justicia secunda Justicia secunda Others
BXGF03512 Helichrysum chionosphaerum Helichrysum chionosphaerum Medicinal Plant
BXGF03608 Achyranthes japonica Achyranthes japonica Medicinal Plant
BXGF03683 Cynanchum viminale Cynanchum viminale Medicinal Plant
BXGF03748 Ventilago leiocarpa Ventilago leiocarpa Medicinal Plant
BXGF03855 Rumex dentatus Rumex dentatus Medicinal Plant
BXGF03988 Rheum coreanum Rheum coreanum Others
BXGF04064 Rumex japonicus Rumex japonicus Medicinal Plant
BXGF04122 Glechoma grandis Glechoma grandis Medicinal Plant
BXGF04205 Aster sedifolius Aster sedifolius Others
BXGF04229 Petunia integrifolia subsp. inflata Petunia integrifolia subsp. inflata Others
BXGF04340 Quercus rubra Quercus rubra Medicinal Plant
BXGF04351 Baccharis potosina Baccharis potosina Others
BXGF04395 Maclura tinctoria Maclura tinctoria Medicinal Plant
BXGF04438 Stevia berlandieri Stevia berlandieri Others
BXGF04499 Ravenia spectabilis Ravenia spectabilis Others
BXGF04539 Rheum palmatum Rheum palmatum Medicinal Plant
BXGF04605 Senna alexandrina Senna alexandrina Medicinal Plant
BXGF04631 Aloe spicata Aloe spicata Medicinal Plant
BXGF04713 Aster tataricus Aster tataricus Medicinal Plant
BXGF04881 Fallopia multiflora Fallopia multiflora Medicinal Plant
BXGF04914 Cassia acutifolia Cassia acutifolia Medicinal Plant
BXGF04916 Cassia mimosoides Cassia mimosoides Medicinal Plant
BXGF04917 Cassia obtusifolia Cassia obtusifolia Medicinal Plant
BXGF04926 Aloe africana Aloe africana Medicinal Plant
BXGF04930 Alvaradoa haitiensis Alvaradoa haitiensis Others
BXGF04936 Cassia occidentalis Cassia occidentalis Medicinal Plant
BXGF04982 Ligusticum chuanxiong Ligusticum chuanxiong Medicinal Plant
BXGF04984 Selaginella labordei Selaginella labordei Others
BXGF04990 Cassia tora Cassia tora Medicinal Plant
BXGF05018 Lavandula vera Lavandula vera Medicinal Plant
BXGF05022 rumex plants rumex plants Others
BXGF05051 Rhamnus Rhamnus Medicinal Plant
BXGF05058 kniphofia ensifolia kniphofia ensifolia Others
BXGF05183 Lanaria lanata Lanaria lanata Others
BXGF05192 Frangula purshiana Frangula purshiana Medicinal Plant
BXGF05224 Cranfillia fluviatilis Cranfillia fluviatilis Medicinal Plant
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF05356 Euodia officinalis Euodia officinalis Others
BXGF05511 Acorus gramineus Acorus gramineus Medicinal Plant
BXGF05524 Rumex nepalensis Rumex nepalensis Medicinal Plant
BXGF05877 Rheum tanguticum Rheum tanguticum Medicinal Plant
BXGF05886 Senna tora Senna tora Medicinal Plant
BXGF06002 Euodia ruticarpa Euodia ruticarpa Others
BXGF06011 Enceliopsis argophylla Enceliopsis argophylla Others
BXGF06071 Acorus tatarinowii Acorus tatarinowii Medicinal Plant
BXGF06095 Rheum undulatum Rheum undulatum Medicinal Plant
BXGF06114 Senna obtusifolia Senna obtusifolia Medicinal Plant
BXGF06217 Morus mongolica Morus mongolica Medicinal Plant
BXGF06281 Miliusa velutina Miliusa velutina Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease